Trial reportPhysiological reports2025
Exploring the effects of outdoor physical work in the heat, with or without sodium bicarbonate supplementation, on markers of acute kidney injury.
Trial report in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Gastrointestinal Symptoms Associated With Sodium Bicarbonate Supplementation Protocols: A Systematic Review.European journal of sport science · 2026Pooled it
- Effect of sodium bicarbonate on performance and markers of kidney and gastrointestinal injury during repeated sprints in the heat.European journal of applied physiology · 2026Trial
- Exploring the effects of outdoor physical work in the heat, with or without sodium bicarbonate supplementation, on markers of acute kidney injury.Physiological reports · 2025Trial
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Acute kidney injury (AKI) has been observed after prolonged physical activity in the heat. Although a range of strategies to reduce the incidence of AKI have been investigated, sodium bicarbonate (SB) supplementation may mitigate metabolic stress during physical exertion and potentially alleviate renal workload by lowering glomerular filtration demand, reducing bicarbonate reabsorption, and preserving kidney microcirculation. Therefore, the primary objective of this study was to investigate the effect of SB ingestion on markers of AKI. Fourteen healthy men and women (n = 6) completed two (SB & placebo) experimental 2-hr outdoor work sessions in the heat (~35°C; ~20% humidity) designed to simulate construction tasks. Changes in acid-base balance, markers of kidney injury (NGAL, TIMP2, IGFBP-7), thermotolerance, and work achieved throughout the experimental trials were analyzed using a linear mixed model with two-way repeated measures. Despite inducing a significant level of alkalosis in the SB trial (7.40 ± 0.03 vs. 7.45 ± 0.03; p < 0.001), no changes were observed in urinary NGAL, TIMP2, or IGFBP-7 concentrations (p > 0.27). Core temperature and heart rate were elevated throughout the work session in the SB condition (mean increase of 0.2 ± 0.1°C and 9 ± 3 bpm; p < 0.025), but the rating of perceived effort was lower when compared to placebo (0.3 ± 0.1 au; p = 0.003). Although the environmental and work stress in the present study did not influence markers of acute AKI, participants were less sensitive to increases in thermoregulatory and cardiovascular strain during a state of metabolic alkalosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.