Evidence map›Paper›PMID 40700166›Full record

ArticleJournal of xenobiotics2025

Skin Wound Healing: The Impact of Treatment with Antimicrobial Nanoparticles and Mesenchymal Stem Cells.

Pavel Rossner, Eliska Javorkova, Michal Sima, Zuzana Simova, Barbora Hermankova, Katerina Palacka, Zuzana Novakova, Irena Chvojkova, Tereza Cervena, Kristyna Vrbova and 4 more

Abstract read
In one paragraph

Article in Journal of xenobiotics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Pavel RossnerDepartment of Toxicology and Molecular Epidemiology, Institute of Experimental Medicine CAS, 14220 Prague, Czech Republic.ORCID 0000-0001-6921-5446
Eliska JavorkovaDepartment of Toxicology and Molecular Epidemiology, Institute of Experimental Medicine CAS, 14220 Prague, Czech Republic.
Michal SimaDepartment of Toxicology and Molecular Epidemiology, Institute of Experimental Medicine CAS, 14220 Prague, Czech Republic.ORCID 0000-0001-6927-8615
Zuzana SimovaDepartment of Toxicology and Molecular Epidemiology, Institute of Experimental Medicine CAS, 14220 Prague, Czech Republic.
Barbora HermankovaDepartment of Toxicology and Molecular Epidemiology, Institute of Experimental Medicine CAS, 14220 Prague, Czech Republic.
Katerina PalackaDepartment of Toxicology and Molecular Epidemiology, Institute of Experimental Medicine CAS, 14220 Prague, Czech Republic.
Zuzana NovakovaDepartment of Toxicology and Molecular Epidemiology, Institute of Experimental Medicine CAS, 14220 Prague, Czech Republic.
Irena ChvojkovaDepartment of Toxicology and Molecular Epidemiology, Institute of Experimental Medicine CAS, 14220 Prague, Czech Republic.
Tereza CervenaDepartment of Toxicology and Molecular Epidemiology, Institute of Experimental Medicine CAS, 14220 Prague, Czech Republic.ORCID 0000-0001-9248-2761
Kristyna VrbovaDepartment of Toxicology and Molecular Epidemiology, Institute of Experimental Medicine CAS, 14220 Prague, Czech Republic.
Anezka VimrovaDepartment of Toxicology and Molecular Epidemiology, Institute of Experimental Medicine CAS, 14220 Prague, Czech Republic.
Jiri KlemaDepartment of Computer Science, Czech Technical University in Prague, 16000 Prague, Czech Republic.ORCID 0000-0003-1753-9435
Andrea RossnerovaDepartment of Toxicology and Molecular Epidemiology, Institute of Experimental Medicine CAS, 14220 Prague, Czech Republic.
Vladimir HolanDepartment of Toxicology and Molecular Epidemiology, Institute of Experimental Medicine CAS, 14220 Prague, Czech Republic.

Funding

Czech Science Foundation 21-17720SMinistry of Education, Youth and Sports of the Czech Republic LM2023053Ministry of Education, Youth and Sports of the Czech Republic LM2023066
6 · The paper itself

Abstract

An investigation into the biological mechanisms initiated in wounded skin following the application of mesenchymal stem cells (MSCs) and nanoparticles (NPs) (Ag, ZnO), either alone or combined, was performed in mice, with the aim of determining the optimal approach to accelerate the healing process. This combined treatment was hypothesized to be beneficial, as it is associated with the production of molecules supporting the healing process and antimicrobial activity. The samples were collected seven days after injury. When compared with untreated wounded animals (controls), the combined (MSCs+NPs) treatment induced the expression of

Indexed as

epigenetic regulationgene expressionimmune responsemesenchymal stem cellsnanoparticlesskin injury

Identifiers

PMID40700166
PMCPMC12285939

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.