ReviewMedical sciences (Basel, Switzerland)2025
Hip Fracture as a Systemic Disease in Older Adults: A Narrative Review on Multisystem Implications and Management.
Review in Medical sciences (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Effectiveness of Robotic Systems with Dynamic Body Weight Support in Post-Traumatic Lower Limb Rehabilitation: A Systematic Review.Medicina (Kaunas, Lithuania) · 2026Pooled it
- Association of multidimensional biomarkers of immune, nutritional, inflammatory, and metabolic status with postoperative outcomes in older hip fracture patients: a systematic review and meta-analysis.Frontiers in nutrition · 2026Pooled it
- Calf Muscle Vein Thrombosis After Hip and Lower-Limb Fracture Surgery: A Systematic Review and Meta-Analysis.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisPooled it
- Frailty Trajectory Within 3 Months After Discharge Among Older Adults Living With Frailty Who Experience Hip Fracture Surgery and Predictors.Journal of advanced nursing · 2026Observational
- Predicting lower extremity deep vein thrombosis in elderly patients with hip fracture: A machine learning model with emphasis on diabetes as a key risk factor.Experimental and therapeutic medicine · 2026Article
- Fragility fracture risk prediction using quantitative magnetic resonance and Vertebral Bone Quality scoring beyond density.World journal of methodology · 2026Review
- Prevalence and Associated Risk Factors of Osteoporosis in Community-Dwelling Older Adults in China: A Cross-Sectional Study of 2533 Participants.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
- Explainable Machine Learning Models for Predicting Functional and Pain Recovery After Fragility Fracture Surgery.Diagnostics (Basel, Switzerland) · 2026Article
- Cumulative Lifestyle Profiles and Osteoporotic Fracture Risk in Older Women: A Nationwide Korean Cohort Study.Healthcare (Basel, Switzerland) · 2026Article
- Functional Occlusal Support, Denture-Related Status and Hip Fracture Risk in Older Adults: A Large Claims-Based Cohort Study.Journal of oral rehabilitation · 2026Article
- When 'No Surgery' Is Chosen: A Five-Domain Framework for Evaluating Ethical Consent in Non-Operative Hip Fracture Care.Journal of evaluation in clinical practice · 2026Article
- Clinical and Inflammatory Determinants of Postoperative Delirium After Hip Fracture Surgery: A Retrospective Cohort Study of 962 Patients.Medicina (Kaunas, Lithuania) · 2026Article
- Article
- Integrated assessment of preoperative nutritional, inflammatory, and metabolic biomarkers and early outcomes in geriatric hip fracture surgery: a retrospective matched study.BMC geriatrics · 2026Article
- Predicting Frailty Trajectories Using Interpretable Machine Learning Among Older Adults Following Hip Surgery: Prospective Longitudinal Study.JMIR aging · 2026Observational
- Article
- When evidence is not the barrier: bridging the implementation gap in orthogeriatric care.European geriatric medicine · 2026Article
- Impact of Postoperative Weight-Bearing Protocols on Prognosis in Geriatric Hip Fracture Patients: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
- Management and optimisation in the preoperative phase for patients with a fractured hip.EFORT open reviews · 2026Review
- The Co-Occurrence of Pertrochanteric Fracture and Acute Coronary Syndrome in a Geriatric Patient: A Case Report and Review of the Literature.Journal of cardiovascular development and disease · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
Hip fractures are among the most serious health events in older adults, frequently leading to disability, loss of independence, and elevated mortality. In 2019, an estimated 9.6 million new cases occurred globally among adults aged ≥ 55 years, with an incidence rate of 681 per 100,000. Despite improved surgical care, one-year mortality remains high (15-30%), and fewer than half of survivors regain their pre-fracture functional status. Traditionally regarded as mechanical injuries, hip fractures are now increasingly recognized as systemic events reflecting and accelerating biological vulnerability and frailty progression. We synthesize evidence across biological, clinical, and social domains to explore the systemic implications of hip fracture, from the acute catabolic response and immune dysfunction to long-term functional decline. The concept of intrinsic capacity, introduced by the World Health Organization, offers a resilience-based framework to assess the multidimensional impact of hip fracture on physical, cognitive, and psychological function. We highlight the importance of orthogeriatric co-management, early surgical intervention, and integrated rehabilitation strategies tailored to the individual's functional reserves and personal goals. Innovations such as digital health tools, biological aging biomarkers, and personalized surgical approaches represent promising avenues to enhance recovery and autonomy. Ultimately, we advocate for a shift toward interdisciplinary, capacity-oriented models of care that align with the goals of healthy aging and enable recovery that transcends survival, focusing instead on restoring function and quality of life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.