Evidence map›Paper›PMID 40700077›Full record

ArticlePathophysiology : the official journal of the International Society for Pathophysiology2025

Prenatal Alcohol Exposure and Congenital Heart Defects: Retinoic Acid Deficiency as a Potential Mechanism in Dextro-Type Transposition of the Great Arteries.

Roberto Paparella, Carolina Putotto, Marco Fiore, Fiorenza Colloridi, Paolo Versacci, Mauro Ceccanti, Bruno Marino, Luigi Tarani

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PubMed Full text at PMC Publisher
In one paragraph

Article in Pathophysiology : the official journal of the International Society for Pathophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Roberto PaparellaDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0001-7020-1471
Carolina PutottoDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0003-3778-3769
Marco FioreInstitute of Biochemistry and Cell Biology (IBBC-CNR), Department of Sensory Organs, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0001-6806-9715
Fiorenza ColloridiDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0003-0853-873X
Paolo VersacciDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0002-4484-4729
Mauro CeccantiSocietà Italiana per il Trattamento dell'Alcolismo e le sue Complicanze (SITAC), 00185 Rome, Italy.ORCID 0000-0001-9981-8715
Bruno MarinoDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, 00185 Rome, Italy.
Luigi TaraniDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0001-5958-9364

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fetal alcohol spectrum disorder (FASD) is a preventable cause of developmental disabilities linked to prenatal alcohol exposure (PAE). Congenital heart defects (CHDs) are frequently observed in FASD, with a notable association between PAE and dextro-type transposition of the great arteries (d-TGA). A potential pathogenetic mechanism of d-TGA in FASD, involving retinoic acid (RA) deficiency due to the interference of ethanol with RA biosynthesis, is proposed. Further investigation is required to understand the timing and impact of alcohol exposure on congenital anomalies, particularly in the context of CHDs.

Indexed as

cardiovascular disorderscongenital heart defectsfetal alcohol spectrum disorderprenatal alcohol exposureretinoic acidtransposition of the great arteries

Identifiers

PMID40700077
PMCPMC12286082

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.