Evidence map›Paper›PMID 40700057›Full record

ArticleAdvances in respiratory medicine2025

Investigation of Individual Variability and Temporal Fluctuations in Exhaled Nitric Oxide (FeNO) Levels in Healthy Individuals.

Emi Yuda, Tomoki Ando, Yukihiro Ishida, Hiroyuki Sakano, Yutaka Yoshida

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advances in respiratory medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Type 2 inflammation accelerates CD4Journal of Zhejiang University. Science. B · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Emi YudaInnovation Center for Semiconductor and Digital Future, Mie University, Tsu 514-0000, Japan.ORCID 0000-0002-1865-7735
Tomoki AndoInnovation Center for Semiconductor and Digital Future, Mie University, Tsu 514-0000, Japan.
Yukihiro IshidaInnovation Center for Semiconductor and Digital Future, Mie University, Tsu 514-0000, Japan.
Hiroyuki SakanoInnovation Center for Semiconductor and Digital Future, Mie University, Tsu 514-0000, Japan.
Yutaka YoshidaInnovation Center for Semiconductor and Digital Future, Mie University, Tsu 514-0000, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Measurement of nitric oxide (NO) concentration in exhaled breath (FeNO) is a quantitative, non-invasive, simple, and safe method for assessing airway inflammation. It serves as a complementary tool to other methods for evaluating airway diseases. However, little is known about the typical NO levels in healthy individuals, including individual differences and the influence of measurement timing. Therefore, this study classified measurement times into four periods and statistically analyzed NO levels in healthy individuals. The mean values among groups were compared using repeated measures ANOVA on six participants. The analysis showed large individual variations in NO levels, resulting in no significant difference (

Indexed as

Circadian RhythmNitric OxideAdultBiomarkersBreath TestsExhalationFemaleHealthy VolunteersHumansMaleTime FactorsYoung AdultBiomarkersNitric Oxideairway inflammationcircadian rhythmexhaled nitric oxide (FeNO)individual variabilityrepeated measures ANOVA

Identifiers

PMID40700057
PMCPMC12286131

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.