Evidence map›Paper›PMID 40700020›Full record

ArticleCell reports2025

IGSF10 is a RET antagonist regulating Ewing sarcoma growth and GnRH neuron migration.

Panneerselvam Jayabal, Xiuye Ma, Maleeha Akram, Hannah Bow, Pranay Mandal, Naira Mansano, Yidong Chen, Susan T Weintraub, Peter J Houghton, Susan Wray and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Panneerselvam JayabalGreehey Children's Cancer Research Institute, The University of Texas Health Science Center, San Antonio, TX 78229, USA.
Xiuye MaGreehey Children's Cancer Research Institute, The University of Texas Health Science Center, San Antonio, TX 78229, USA.
Maleeha AkramCellular and Developmental Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Hannah BowCellular and Developmental Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Pranay MandalCellular and Developmental Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Naira MansanoCellular and Developmental Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Yidong ChenGreehey Children's Cancer Research Institute, The University of Texas Health Science Center, San Antonio, TX 78229, USA; Department of Population Health Sciences, The University of Texas Health Science Center, San Antonio, TX 78229, USA; Mays Cancer Center, The University of Texas Health Science Center, San Antonio, TX 78229, USA.
Susan T WeintraubMays Cancer Center, The University of Texas Health Science Center, San Antonio, TX 78229, USA; Department of Biochemistry and Structural Biology, The University of Texas Health Science Center, San Antonio, TX 78229, USA.
Peter J HoughtonGreehey Children's Cancer Research Institute, The University of Texas Health Science Center, San Antonio, TX 78229, USA; Mays Cancer Center, The University of Texas Health Science Center, San Antonio, TX 78229, USA; Department of Molecular Medicine, The University of Texas Health Science Center, San Antonio, TX 78229, USA.
Susan WrayCellular and Developmental Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Yuzuru ShiioGreehey Children's Cancer Research Institute, The University of Texas Health Science Center, San Antonio, TX 78229, USA; Mays Cancer Center, The University of Texas Health Science Center, San Antonio, TX 78229, USA; Department of Biochemistry and Structural Biology, The University of Texas Health Science Center, San Antonio, TX 78229, USA. Electronic address: shiio@uthscsa.edu.

Funding

TISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Robin Jean Leach · 1991 to 2026
$59.1M
Development And Regulation Of The Luteinizing Hormone Releasing Hormone SystemZIANS002824 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI WRAY, SUSAN · 2009 to 2025
$41.2M
XENOGRAFT AND CELL LINE COREP01CA165995 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI LONDON, CHERYL A · 2013 to 2017
$7.9M
The Luteinizing Hormone Releasing Hormone SystemZ01NS002824 · NINDS · NEUROLOGICAL DISORDERS AND STROKE · PI WRAY, SUSAN · 1991 to 2008
$4.9M
The role of the receptor complex and the cofactors in IGSF10 signalingU01CA283414 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI YUZURU SHIIO · 2024 to 2026
$1.0M
Orbitrap XL/ETD Mass SpectrometerS10RR025111 · NCRR · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI WEINTRAUB, SUSAN T · 2009 to 2009
$776k
Illumina NovaSeq 6000 Sequencing SystemS10OD030311 · OD · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI LAI, ZHAO · 2021 to 2021
$600k
The role of the receptor complex and the cofactors in IGSF10 signalingR01CA283414 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SHIIO, YUZURU · 2023 to 2023
$355k
Intramural NIH HHS Z01 NS002824Intramural NIH HHS ZIA NS002824NCI NIH HHS P01 CA165995NCI NIH HHS P30 CA054174NCI NIH HHS R01 CA283414NCI NIH HHS U01 CA283414NCRR NIH HHS S10 RR025111NIH HHS S10 OD030311
6 · The paper itself

Abstract

RET is a receptor tyrosine kinase that plays important roles in development, cancers, and Parkinson's disease. Here, we identify immunoglobulin superfamily member 10 (IGSF10) as a RET antagonist. We show that Ewing sarcoma depends on IGSF10 and that IGSF10 prevents RET-mediated activation of cdc42, a Rho family G protein and a key regulator of Ewing sarcoma growth as well as cell migration. We demonstrate that IGSF10 binds RET and GAS1, a cell surface RET inhibitor, and assembles an inhibitory RET-GAS1 complex, preventing a stimulatory RET-GFRA complex. IGSF10 mutations are associated with delayed puberty, and IGSF10 is shown to be necessary for the proper migration of gonadotropin-releasing hormone (GnRH) neurons. We show that the IGSF10-RET-GAS1-cdc42 pathway regulates migration of GnRH neurons and that IGSF10 mutants linked to delayed puberty are defective in RET-cdc42 regulation. These results reveal a critical role of IGSF10 as a RET antagonist in Ewing sarcoma and GnRH neurons.

Indexed as

Gonadotropin-Releasing HormoneImmunoglobulinsNeuronsProto-Oncogene Proteins c-retSarcoma, EwingAnimalscdc42 GTP-Binding ProteinCell Line, TumorCell MovementCell ProliferationHumansMiceSignal Transductioncdc42 GTP-Binding ProteinGonadotropin-Releasing HormoneImmunoglobulinsProto-Oncogene Proteins c-retCP: CancerCP: NeuroscienceEwing sarcomaGAS1GnRH neuronIGSF10proteomicsRETsecretome

Identifiers

PMID40700020
PMCPMC12453587

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.