Evidence map›Paper›PMID 40699919›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

SETDB1 ensures the continuity of embryonic to adult neural stem cells through metabolic alterations in the dentate gyrus.

Yunyun Huang, Yue Zhu, Yueyan Zhu, Yan Jiang, Yunli Xie

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yunyun Huang *Department of Anesthesia, State Key Laboratory of Brain Function and Disorders and Ministry of Education Frontiers Center for Brain Science, Institutes of Brain Science, and Zhongshan Hospital, Fudan University, Shanghai 200032, China.ORCID 0000-0003-1418-1335
Yue Zhu *Department of Anesthesia, State Key Laboratory of Brain Function and Disorders and Ministry of Education Frontiers Center for Brain Science, Institutes of Brain Science, and Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Yueyan ZhuDepartment of Anesthesia, State Key Laboratory of Brain Function and Disorders and Ministry of Education Frontiers Center for Brain Science, Institutes of Brain Science, and Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Yan JiangDepartment of Anesthesia, State Key Laboratory of Brain Function and Disorders and Ministry of Education Frontiers Center for Brain Science, Institutes of Brain Science, and Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Yunli XieDepartment of Anesthesia, State Key Laboratory of Brain Function and Disorders and Ministry of Education Frontiers Center for Brain Science, Institutes of Brain Science, and Zhongshan Hospital, Fudan University, Shanghai 200032, China.ORCID 0000-0002-7126-0972

Funding

National Natural Science Fundation of China 32271020STI2030-Major projects 2021ZD0202304
6 · The paper itself

Abstract

Embryonic neural progenitors give rise to adult neural stem cells (aNSCs), which share transcriptomic similarities with astrocytes while sustaining neurogenesis in the adult brain. How embryonic neural progenitors transit into aNSCs while preventing astrocyte fate to maintain the aNSC pool remains unclear. Here, we found that the

Indexed as

Adult Stem CellsDentate GyrusHistone-Lysine N-MethyltransferaseNeural Stem CellsAnimalsAstrocytesCell DifferentiationElectron Transport Complex IVMiceNeurogenesisNeuronsOxidative PhosphorylationElectron Transport Complex IVHistone-Lysine N-MethyltransferaseSETDB1 protein, mouseadult neural stem celladult neurogenesisneural progenitorSETDB1

Identifiers

PMID40699919
PMCPMC12318225

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.