Sexual failure decreases sweet taste perception in male

Gaohang Wang, Wei Qi, Rui Huang, Liming Wang

Abstract read

In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Gaohang WangInstitute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen, China.

Wei QiDepartment of Biology, Stanford University, Stanford, United States.

Rui HuangGuangyang Bay Laboratory, Chongqing Institute for Brain and Intelligence, Chongqing, China.

Liming WangInstitute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen, China.ORCID https://orcid.org/0000-0002-7256-8776

Funding

National Natural Science Foundation of China 32071006National Natural Science Foundation of China 32271008

6 · The paper itself

Abstract

Sweet taste perception, a critical aspect of the initiation of feeding behavior, is primarily regulated by an animal's internal metabolic state. However, non-metabolic factors, such as motivational and emotional states, can also influence peripheral sensory processing and hence feeding behavior. While mating experience is known to induce motivational and emotional changes, its broader impact on other innate behaviors, such as feeding, remains largely uncharacterized. In this study, we demonstrated that the mating failure of male fruit flies suppressed sweet taste perception via dopamine signaling in specific neural circuitry. Upon repetitive failure in courtship, male flies exhibited a sustained yet reversible decline of sweet taste perception, as measured by the proboscis extension reflex (PER) towards sweet tastants as well as the neuronal activity of sweet-sensing Gr5a

Indexed as

DopamineDopaminergic NeuronsDrosophila melanogasterSexual Behavior, AnimalSignal TransductionTaste PerceptionAnimalsDrosophila ProteinsFemaleMaleDopamineDrosophila ProteinsD. melanogasterdopaminefeedingGr5a+ neuronsmale Drosophilamatingneurosciencesweet taste perception

Identifiers

PMID40699890

DOI10.7554/eLife.105094

PMCPMC12286605

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.