Evidence map›Paper›PMID 40699874›Full record

ArticleCurrent issues in molecular biology2025

L-Ascorbic Acid (LAA) Supplementation as a Potential Treatment for Skin Aging: Regulation of Adipose Tissue Mesenchymal Stem Cells (AT-MSCs) Protein Secretion.

Komang Ardi Wahyuningsih, I Gede Eka Wiratnaya, I Wayan Weta, I Gde Raka Widiana, Wimpie I Pangkahila, Ida Ayu Ika Wahyuniari, I Made Muliarta, Veronika Maria Sidharta, Assyafiya Salwa

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Article in Current issues in molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Komang Ardi WahyuningsihDoctoral Program, Faculty of Medicine, Udayana University, Denpasar, Bali 80232, Indonesia.ORCID 0000-0002-5549-6571
I Gede Eka WiratnayaDoctoral Program, Faculty of Medicine, Udayana University, Denpasar, Bali 80232, Indonesia.
I Wayan WetaDoctoral Program, Faculty of Medicine, Udayana University, Denpasar, Bali 80232, Indonesia.
I Gde Raka WidianaDoctoral Program, Faculty of Medicine, Udayana University, Denpasar, Bali 80232, Indonesia.
Wimpie I PangkahilaDoctoral Program, Faculty of Medicine, Udayana University, Denpasar, Bali 80232, Indonesia.
Ida Ayu Ika WahyuniariDoctoral Program, Faculty of Medicine, Udayana University, Denpasar, Bali 80232, Indonesia.
I Made MuliartaDoctoral Program, Faculty of Medicine, Udayana University, Denpasar, Bali 80232, Indonesia.
Veronika Maria SidhartaDepartment of Histology, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, North Jakarta, Jakarta 14440, Indonesia.ORCID 0000-0002-9982-6528
Assyafiya SalwaFaculty of Medicine, UPN Veteran Jakarta, Jakarta 12450, Indonesia.ORCID 0009-0006-4058-4137

Funding

The Indonesian Education Scholarship, The Center for Higher Education Funding and Assess-ment, Ministry of Higher Education, Science, and Technology of Republic Indonesia, and En-dowment Fund for Education Agency, Ministry of Finance of Republic Indonesia
6 · The paper itself

Abstract

Skin aging is mostly caused by the accumulation of reactive oxygen species (ROS) that lead to cellular dysfunction. One promising therapy for skin aging is the secretome product of adipose tissue mesenchymal stem cells (AT-MSCs). L-ascorbic acid (LAA) is an essential molecule for preventing oxidative stress as an external antioxidant agent and has been used in chemical therapy for skin aging. In this study, we evaluated the effects of LAA on cell morphology, the number of cells, cell viability, and the paracrine secretion of preconditioned AT-MSCs in in vitro culture with LAA in 100 and 200 µg/mL compared with an untreated culture with LAA as a control. LAA supplementation in both concentrations improved the morphology of cells without affecting the cell viability. However, there was no significant improvement in the number of cells even though the trend showed an enhancement of the number of cells. The total protein of the secretome decreased in the LAA preconditioning group. However, preconditioning AT-MSCs in in vitro culture with LAA improved the levels of insulin-like growth factor 1 (IGF-1), transforming growth factor β1 (TGF-β1), and interleukin 6 (IL-6) which are essential proteins for skin aging in regulating ROS.

Indexed as

adipose tissue mesenchymal stem cells (AT-MSCs)L-ascorbic acid (LAA)reactive oxygen species (ROS)skin aging

Identifiers

PMID40699874
PMCPMC12191563

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