Evidence map›Paper›PMID 40699757›Full record

ArticleCurrent issues in molecular biology2025

Ethanol Extract of Adlay Hulls Suppresses Acute Myeloid Leukemia Cell Proliferation via PI3K/Akt Pathway Inhibition.

Guangjie Li, Wenyuan Yang, Jiahui Xu, Ziqian Liu, Zhijian Li, Xiaoqiu Wu, Tongtong Li, Ruoxian Wang, Yamin Zhu, Ning Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current issues in molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Guangjie LiInternational Research Centre for Food and Health, College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China.
Wenyuan YangSchool of Life Sciences, Henan University, Kaifeng 475003, China.ORCID 0009-0002-9160-5277
Jiahui XuInternational Research Centre for Food and Health, College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China.
Ziqian LiuInternational Research Centre for Food and Health, College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China.
Zhijian LiInternational Research Centre for Food and Health, College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China.
Xiaoqiu WuInternational Research Centre for Food and Health, College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China.
Tongtong LiInternational Research Centre for Food and Health, College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China.
Ruoxian WangInternational Research Centre for Food and Health, College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China.
Yamin ZhuInternational Research Centre for Food and Health, College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China.ORCID 0000-0002-0431-5160
Ning LiuInternational Research Centre for Food and Health, College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China.ORCID 0000-0002-7009-9187

Funding

CSPFTZ Lingang Special Area Marine Biomedical Innovation Platform Grant No. RWS2024003Natural Science Foundation of Shanghai No. 21ZR1427300Shanghai Frontiers Research Center of the Hadal Biosphere and the National Natural Science Foundation of China No. 82173731Shanghai Magnolia Talent Plan Pujiang Project Grant No.24PJD042
6 · The paper itself

Abstract

Acute myeloid leukemia (AML) is a common hematologic malignancy in the elderly with frequent relapse and poor prognosis. Limited treatments highlight the need for novel natural anticancer compounds. Adlay, valued for its medicinal and dietary properties, exhibits anti-inflammatory and anticancer effects. However, research on adlay hulls, particularly their anti-AML bioactive molecules, remains insufficient. This study evaluated the effects of adlay hull ethanol extract (AHE) on AML cell proliferation and apoptosis. AHE was extracted with ethanol and fractionated using n-hexane, ethyl acetate, and n-butanol, followed by silica gel chromatography. Cytotoxicity was assessed via the CCK-8 assay, and mechanisms were analyzed by flow cytometry and Western blotting. The bioactive components were characterized by UPLC-IMS-QTOF-MS. AHE-EA-C (ethyl acetate fraction C) inhibited AML cell proliferation, induced G0/G1 phase arrest, and promoted apoptosis. It suppressed the PI3K/Akt pathway by reducing PI3K and Akt phosphorylation. Using UPLC-IMS-QTOF-MS analysis, a total of 52 compounds with potential anti-AML activity were identified in AHE-EA-C, among which neohesperidin and cycloartanol have been previously reported to exhibit anti-AML activity and thus hold promise as candidates for further development as AML inhibitors. This study is the first to identify adlay hull bioactive components and their anti-AML mechanisms via PI3K/Akt pathway inhibition, providing a foundation for developing natural anti-AML therapies.

Indexed as

acute myeloid leukemiaadlay hull extractapoptosisbioactive componentsPI3K/Akt pathwayproliferation

Identifiers

PMID40699757
PMCPMC12109684

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.