Evidence map›Paper›PMID 40699729›Full record

ReviewCurrent issues in molecular biology2025

CRISPR-Cas9 in the Tailoring of Genetically Engineered Animals.

Wiktoria Urban, Marta Kropacz, Maksymilian Łach, Anna Jankowska

Abstract readReview
In one paragraph

Review in Current issues in molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Wiktoria UrbanDepartment of Cell Biology, Poznan University of Medical Sciences, 61-701 Poznań, Poland.ORCID 0000-0002-1009-5416
Marta KropaczDepartment of Cell Biology, Poznan University of Medical Sciences, 61-701 Poznań, Poland.
Maksymilian ŁachDepartment of Cell Biology, Poznan University of Medical Sciences, 61-701 Poznań, Poland.
Anna JankowskaDepartment of Cell Biology, Poznan University of Medical Sciences, 61-701 Poznań, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CRISPR-Cas9 enables targeted genome editing and has become a pivotal tool in biomedical research and animal genome engineering. This review highlights its application in generating genetically modified animals used as preclinical disease models, bioreactors for recombinant protein production, and potential sources of xenotransplantation organs. We also discuss its role in improving livestock traits, welfare, and breeding efficiency. The benefits and limitations of CRISPR-Cas9 are examined, emphasizing its transformative potential in research and agricultural biotechnology.

Indexed as

CRISPR-Cas9genetically engineered animalsgenome editingmodel organismsxenotransplantation

Identifiers

PMID40699729
PMCPMC12109904

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.