Evidence map›Paper›PMID 40699727›Full record

ArticleCurrent issues in molecular biology2025

Investigating the Therapeutic Potential of Crude Leech Saliva Based on Its Anticancer, Antioxidant, and Anti-Inflammatory Effects.

Alican Bilden, İlhan Sabancılar, Serap Yalçın Azarkan, Kenan Karadağlı, Seçkin Kaya, Merve Kahraman, Muttalip Çiçek

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In one paragraph

Article in Current issues in molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alican BildenDepartment of Medical Parasitology, Faculty of Medicine, Kırşehir Ahi Evran University, Kırşehir 40100, Turkey.ORCID 0000-0003-1119-3859
İlhan SabancılarMedical Services and Techniques Department, Bitlis Eren University, Bitlis 13100, Turkey.ORCID 0000-0002-0773-2752
Serap Yalçın AzarkanDepartment of Medical Pharmacology, Faculty of Medicine, Kırşehir Ahi Evran University, Kırşehir 40100, Turkey.
Kenan KaradağlıDepartment of Medical Parasitology, Faculty of Medicine, Siirt Education and Research Hospital, Siirt 56100, Turkey.
Seçkin KayaDepartment of Medical Biochemistry, Institute of Health Sciences, Ataturk University, Erzurum 25240, Turkey.ORCID 0000-0001-8771-0109
Merve KahramanDepartment of Medical Parasitology, Faculty of Medicine, Kırşehir Ahi Evran University, Kırşehir 40100, Turkey.
Muttalip ÇiçekDepartment of Medical Parasitology, Faculty of Medicine, Kırşehir Ahi Evran University, Kırşehir 40100, Turkey.ORCID 0000-0003-4807-4482

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Leech therapy is a biotherapeutic approach that has been traditionally used for centuries and is currently being re-evaluated in modern medicine. The efficacy of this treatment is attributed to various bioactive compounds found in leech saliva, which exhibit anticoagulant, anti-inflammatory, antioxidant, and anticancer properties. It has been demonstrated that leech saliva possesses the potential to modulate inflammatory processes and apoptotic mechanisms. In this study, the therapeutic potential of the saliva of

Indexed as

antioxidant activitycell viabilitycytokinesHirudo verbanaHUVECOVCAR3

Identifiers

PMID40699727
PMCPMC12109681

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.