Evidence map›Paper›PMID 40699676›Full record

ReviewCurrent issues in molecular biology2025

Cytokine Therapy in Bladder Cancer: Mechanisms, Efficacy, and Future Prospects.

Hayden J Oyler, Layne G Bruton, Austin J Maher, Darien A Yu, Nicholas W Shely, Mark R Wakefield, Yujiang Fang

Abstract readReview
In one paragraph

Review in Current issues in molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hayden J OylerDepartment of Microbiology, Immunology & Pathology, Des Moines University, West Des Moines, IA 50266, USA.ORCID 0009-0008-4790-1945
Layne G BrutonDepartment of Microbiology, Immunology & Pathology, Des Moines University, West Des Moines, IA 50266, USA.
Austin J MaherDepartment of Surgery, School of Medicine, University of Missouri, Columbia, MO 65211, USA.
Darien A YuDepartment of Surgery, School of Medicine, University of Missouri, Columbia, MO 65211, USA.
Nicholas W ShelyDepartment of Microbiology, Immunology & Pathology, Des Moines University, West Des Moines, IA 50266, USA.
Mark R WakefieldDepartment of Surgery, School of Medicine, University of Missouri, Columbia, MO 65211, USA.ORCID 0000-0003-2598-7895
Yujiang FangDepartment of Microbiology, Immunology & Pathology, Des Moines University, West Des Moines, IA 50266, USA.

Funding

Dr. Yujiang Fang IOER 112-3119
6 · The paper itself

Abstract

Cytokine therapy is a rapidly evolving field in bladder cancer research, with treatments designed to enhance immune responses, improve targeting, and promote tumor cell recognition and elimination. This review explores pro-inflammatory cytokines, anti-inflammatory cytokines, engineered cytokines and fusion proteins, and combination therapies. Challenges include risks of toxicity, immune suppression, and the potential for promoting metastasis. Despite these obstacles, the potential successes of cytokine therapies highlight the importance of continued investigation into their use for developing safe, effective, and minimally invasive treatments for bladder cancer.

Indexed as

anti-inflammatory cytokinesbladder cancercytokine therapyengineered cytokinesfusion proteinsimmunotherapypro-inflammatory cytokines

Identifiers

PMID40699676
PMCPMC12025466

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.