Evidence map›Paper›PMID 40699670›Full record

ArticleCurrent issues in molecular biology2025

miR-27a rs895819 Polymorphism and Recurrent Pregnancy Loss in Caucasian Women: A Novel Genetic Risk Factor in a Challenging Fertility Dilemma.

Georgia Panagou, Anastasios Potiris, Dimitra Dedousi, Despoina Mavrogianni, Ioanna Vassilaki, Athanasios Zikopoulos, Efthalia Moustakli, Antonios Sfakianakis, Nikolaos Kathopoulis, Angeliki Gerede and 4 more

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Article in Current issues in molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

14 authors.

Georgia PanagouFirst Department of Obstetrics and Gynecology, Alexandra Hospital, Medical School, National and Kapodistrian University of Athens, 115 28 Athens, Greece.
Anastasios PotirisThird Department of Obstetrics and Gynecology, University General Hospital "ATTIKON", Medical School, National and Kapodistrian University of Athens, 124 62 Athens, Greece.ORCID 0000-0001-7716-1521
Dimitra DedousiFirst Department of Obstetrics and Gynecology, Alexandra Hospital, Medical School, National and Kapodistrian University of Athens, 115 28 Athens, Greece.ORCID 0009-0000-4645-2377
Despoina MavrogianniFirst Department of Obstetrics and Gynecology, Alexandra Hospital, Medical School, National and Kapodistrian University of Athens, 115 28 Athens, Greece.
Ioanna VassilakiFirst Department of Obstetrics and Gynecology, Alexandra Hospital, Medical School, National and Kapodistrian University of Athens, 115 28 Athens, Greece.
Athanasios ZikopoulosThird Department of Obstetrics and Gynecology, University General Hospital "ATTIKON", Medical School, National and Kapodistrian University of Athens, 124 62 Athens, Greece.ORCID 0009-0002-9553-6803
Efthalia MoustakliLaboratory of Medical Genetics, Faculty of Medicine, School of Health Sciences, University of Ioannina, 451 10 Ioannina, Greece.ORCID 0009-0005-3333-2620
Antonios SfakianakisHomerton Fertility Centre, Homerton University Hospital, London E9 6SR, UK.
Nikolaos KathopoulisFirst Department of Obstetrics and Gynecology, Alexandra Hospital, Medical School, National and Kapodistrian University of Athens, 115 28 Athens, Greece.ORCID 0000-0002-0031-809X
Angeliki GeredeDepartment of Obstetrics and Gynecology, Democritus University of Thrace, 691 00 Campus, Greece.
Periklis PanagopoulosThird Department of Obstetrics and Gynecology, University General Hospital "ATTIKON", Medical School, National and Kapodistrian University of Athens, 124 62 Athens, Greece.
Ekaterini DomaliFirst Department of Obstetrics and Gynecology, Alexandra Hospital, Medical School, National and Kapodistrian University of Athens, 115 28 Athens, Greece.ORCID 0000-0001-8899-3040
Peter DrakakisThird Department of Obstetrics and Gynecology, University General Hospital "ATTIKON", Medical School, National and Kapodistrian University of Athens, 124 62 Athens, Greece.
Sofoklis StavrosThird Department of Obstetrics and Gynecology, University General Hospital "ATTIKON", Medical School, National and Kapodistrian University of Athens, 124 62 Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis case-control study investigates whether miR-27a rs895819 A>G polymorphism is associated with an increased risk of recurrent pregnancy loss (RPL) in Caucasian Greek women.

methodsThis study included 93 women with at least two unexplained miscarriages before the 24th week of gestation (RPL group) and 107 women with no pregnancy loss history (control group). The miR-27a rs895819 A>G polymorphism was detected using PCR amplification, followed by DraIII-HF restriction enzyme digestion.

resultsThe GG genotype was linked to a significantly higher risk of RPL (

conclusionsTo our knowledge, this is the first study demonstrating that the miR-27a A>G polymorphism was significantly associated with a higher risk of recurrent miscarriage in Caucasian women. These findings provide evidence that the GG genotype may serve as a potential genetic marker for identifying women at higher risk of recurrent miscarriage, offering valuable insights for genetic counseling and reproductive medicine.

Indexed as

infertilitymiR-27a genemiscarriagerecurrent pregnancy loss (RPL)rs895819 polymorphism

Identifiers

PMID40699670
PMCPMC12025444

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