Evidence map›Paper›PMID 40699661›Full record

ReviewCurrent issues in molecular biology2025

Inhibition of Inflammatory Regulators for Chronic Obstructive Pulmonary Disease (COPD) Treatment from Indonesian Medicinal Plants: A Systematic Review.

Dyah Iswantini, Min Rahminiwati, Trivadila Trivadila, Siti Sadiah, Novriyandi Hanif, Rut Novalia Rahmawati Sianipar, Susi Indariani

Abstract readReview
In one paragraph

Review in Current issues in molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Development of Wedelia (Current issues in molecular biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dyah IswantiniDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, IPB University, Bogor 16680, Indonesia.ORCID 0009-0007-5776-4959
Min RahminiwatiTropical Biopharmaca Research Center, IPB University, Bogor 16128, Indonesia.
Trivadila TrivadilaDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, IPB University, Bogor 16680, Indonesia.ORCID 0000-0003-0939-4635
Siti SadiahTropical Biopharmaca Research Center, IPB University, Bogor 16128, Indonesia.ORCID 0000-0001-7513-4431
Novriyandi HanifDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, IPB University, Bogor 16680, Indonesia.ORCID 0000-0001-9570-3750
Rut Novalia Rahmawati SianiparDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, IPB University, Bogor 16680, Indonesia.ORCID 0000-0003-1592-0558
Susi IndarianiTropical Biopharmaca Research Center, IPB University, Bogor 16128, Indonesia.

Funding

National Research and Innovation Agency (BRIN Indonesia) 41781/IT3.D10/PT.01.03/P/B/2023
6 · The paper itself

Abstract

A characteristic of Chronic Obstructive Pulmonary Disease (COPD) is the inflammation of the respiratory pathway. Inflammatory regulators affected in COPD include cyclooxygenase-2 (COX-2), tumor necrosis factor-alpha (TNF-α), interleukin (IL-1β), and interleukin-6 (IL-6). Therefore, this systematic review aimed to investigate the biological activity of Indonesian medicinal plants as anti-inflammation through in vitro, in silico, and in vivo studies. A digital search was conducted using Scopus, Google Scholar, and PubMed online databases to find relevant articles by applying specific keywords related to the subject of interest. The results showed 18 studies that reported five Indonesian medicinal plants proven to inhibit inflammation regulation. The five plants were

Indexed as

COPDIndonesiainflammationnatural resourcessystematic review

Identifiers

PMID40699661
PMCPMC12025578

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.