Evidence map›Paper›PMID 40699647›Full record

ArticleCurrent issues in molecular biology2025

Effects of Caffeine on THP-1 Myelogenous Cell Inflammatory Gene Expression.

Zeyar T Htun, Thomas M Raffay, Richard J Martin, Peter M MacFarlane, Tracey L Bonfield

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current issues in molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Intermittent hypoxia and caffeine in infants born preterm: the ICAF Randomized Clinical Trial.Archives of disease in childhood. Fetal and neonatal edition · 2026
    Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zeyar T HtunDivision of Neonatology, Department of Pediatrics, New York University Grossman Long Island School of Medicine, Mineola, NY 11501, USA.ORCID 0000-0002-0768-1887
Thomas M RaffayDivision of Neonatology, Department of Pediatrics, Rainbow Babies & Children's Hospital, Case Western Reserve University, Cleveland, OH 44106, USA.ORCID 0000-0002-6572-8719
Richard J MartinDivision of Neonatology, Department of Pediatrics, Rainbow Babies & Children's Hospital, Case Western Reserve University, Cleveland, OH 44106, USA.
Peter M MacFarlaneDivision of Neonatology, Department of Pediatrics, Rainbow Babies & Children's Hospital, Case Western Reserve University, Cleveland, OH 44106, USA.ORCID 0000-0002-5373-7095
Tracey L BonfieldDepartment of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH 44106, USA.

Funding

Little Giraffe Foundation CON238002
6 · The paper itself

Abstract

Caffeine is administered to preterm infants in neonatal intensive care units for prevention and treatment of apnea of prematurity. Although caffeine's primary effect is to impact the respiratory drive of preterm infants, caffeine also has anti-inflammatory properties. This study investigated the role of caffeine on the inflammatory gene expression in THP-1 pre-monocytes exposed to lipopolysaccharide (LPS) in vitro, mimicking a clinical pro-inflammatory scenario. The effects of different physiologic dosages of caffeine administration post-LPS (treatment with caffeine) and pre-LPS (prophylaxis with caffeine) on pro-inflammatory gene expressions (

Indexed as

caffeineinflammationmonocytes

Identifiers

PMID40699647
PMCPMC12025982

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.