Evidence map›Paper›PMID 40699635›Full record

ReviewCurrent issues in molecular biology2025

Recent Advances in Fluorescence Resonance Energy Transfer (FRET) Biosensors for Exosomes.

Feng Huang, Zhenyu Xie, Qianjiao Zhang, Shah Zada, Ruhan Lin, Yanmei Deng, Qifeng Liu, Huizhi Chen, Hui Zhou, Huilai Miao and 1 more

Abstract readReview
In one paragraph

Review in Current issues in molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Numerical analysis of WSFrontiers in bioengineering and biotechnology · 2025
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Feng HuangKey Laboratory of Liver Injury Diagnosis and Repair, and Department of Hepatobiliary Surgery, The 2nd Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China.
Zhenyu XieDongguan Key Laboratory of Advanced Drug Delivery and Biosensing Research and Development, School of Pharmacy and Dongguan Innovation Institute, Guangdong Medical University, Dongguan 523808, China.
Qianjiao ZhangDongguan Key Laboratory of Advanced Drug Delivery and Biosensing Research and Development, School of Pharmacy and Dongguan Innovation Institute, Guangdong Medical University, Dongguan 523808, China.
Shah ZadaDongguan Key Laboratory of Advanced Drug Delivery and Biosensing Research and Development, School of Pharmacy and Dongguan Innovation Institute, Guangdong Medical University, Dongguan 523808, China.
Ruhan LinDongguan Key Laboratory of Advanced Drug Delivery and Biosensing Research and Development, School of Pharmacy and Dongguan Innovation Institute, Guangdong Medical University, Dongguan 523808, China.
Yanmei DengDongguan Key Laboratory of Advanced Drug Delivery and Biosensing Research and Development, School of Pharmacy and Dongguan Innovation Institute, Guangdong Medical University, Dongguan 523808, China.
Qifeng LiuDongguan Key Laboratory of Advanced Drug Delivery and Biosensing Research and Development, School of Pharmacy and Dongguan Innovation Institute, Guangdong Medical University, Dongguan 523808, China.
Huizhi ChenDongguan Key Laboratory of Advanced Drug Delivery and Biosensing Research and Development, School of Pharmacy and Dongguan Innovation Institute, Guangdong Medical University, Dongguan 523808, China.
Hui ZhouDongguan Key Laboratory of Advanced Drug Delivery and Biosensing Research and Development, School of Pharmacy and Dongguan Innovation Institute, Guangdong Medical University, Dongguan 523808, China.ORCID 0000-0003-0572-8976
Huilai MiaoKey Laboratory of Liver Injury Diagnosis and Repair, and Department of Hepatobiliary Surgery, The 2nd Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China.
Yubin ZhouKey Laboratory of Liver Injury Diagnosis and Repair, and Department of Hepatobiliary Surgery, The 2nd Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China.ORCID 0000-0002-6811-1239

Funding

College Students' innovation and entrepreneurship training program 202410571010, S202410571059, S202410571061, S202410571054, 202310571001, 202310571004, 202310571024College Students' innovation experiment program of Guangdong Medical University FYDM004Construction Project of Nano Technology and Application Engineering Research Center of Guangdong Medical University 4SG24179GDongguan Social Development Technology Project-Key Project 20231800940842Featured Innovation Projects for General Colleges and Universities of Guangdong Province 2022KTSCX042Funds for PhD Researchers of Guangdong Medical University 4SG23184GFunds for PhD Researchers of Guangdong Medical University GDMUB2021022Guangdong Medical University Clinical & Basic Science and Technology Innovation Special Pro-gram GDMULCJC2024063Guangdong Medical University Clinical & Basic Science and Technology Innovation Special Pro-gram GDMULCJC2024139Guangdong Medical University Undergraduate Innovation and Entrepreneurship Education Base 2JD24016Medical Scientific Research Foundation of Guangdong Province A2023241Songshan Lake Science and Technology Correspondent Project 20234403-01KCJ-GSpecial projects in key areas for general colleges and universities of Guangdong Province 2021ZDZX2061Special projects in key areas for general colleges and universities of Guangdong Province 2024ZDZX2068This work thanks the support from Guangdong Basic and Applied Basic Research Foundation 2021B1515140006
6 · The paper itself

Abstract

Cancer is a significant global health challenge, where early diagnosis is crucial for enhancing patient survival and mitigating the treatment burden on patients. Exosomes are extracellular vesicles released through the fusion of multivesicular bodies with cell membranes, carrying disease-associated information from donor cells. This makes exosomes a key biomarker in liquid biopsy analysis, particularly for early cancer detection. Developing cost-effective, straightforward, and sensitive exosome biosensing technologies is of significant practical importance. To date, a large number of fluorescence-based exosome biosensors have relied on the Fluorescence Resonance Energy Transfer (FRET) principle. This review introduces the basic background of the field and the principle of FRET-based exosome sensors, followed by a systematic summary of their progress categorized by different transduction elements or mechanisms. Finally, this work discusses the current challenges in the field and proposes potential solutions and future prospects, aiming to encourage and inspire the development of new approaches for advanced FRET exosome biosensors.

Indexed as

biosensorsexosomesfluorescencefluorescence resonance energy transfer (FRET)nanomaterials

Identifiers

PMID40699635
PMCPMC12025574

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.