Evidence map›Paper›PMID 40699548›Full record

ArticleVeterinary medicine and science2025

Long-Term Maintenance of High Neutralizing Anti-SARS-CoV-2 Antibodies Titres in Mares' Milk and Offspring Serum After Pregnant Mares Immunization With SARS-CoV-2 Spike Protein.

Victor Augusto Roncaglia-Pereira, Carlos Henrique Dumard, Marcos Monteiro-Machado, Paulo A Melo, Juliana Fonseca, Leonardo Meirelles, Luis Cunha-Ribeiro, Patrícia Souza, Jerson Lima da Silva, Leda Castilho and 3 more

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In one paragraph

Article in Veterinary medicine and science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Victor Augusto Roncaglia-PereiraInstitute of Medical Biochemistry Leopoldo de Meis and National Institute of Science and Technology for Structural Biology and Bioimaging, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Rio de Janeiro, Brazil.ORCID 0000-0002-5160-8062
Carlos Henrique DumardInstitute of Medical Biochemistry Leopoldo de Meis and National Institute of Science and Technology for Structural Biology and Bioimaging, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Rio de Janeiro, Brazil.
Marcos Monteiro-MachadoLaboratório de Farmacologia das Toxinas, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Paulo A MeloLaboratório de Farmacologia das Toxinas, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Juliana FonsecaVital Brazil Institute, Niterói, Rio de Janeiro, Brazil.
Leonardo MeirellesVital Brazil Institute, Niterói, Rio de Janeiro, Brazil.
Luis Cunha-RibeiroVital Brazil Institute, Niterói, Rio de Janeiro, Brazil.
Patrícia SouzaVital Brazil Institute, Niterói, Rio de Janeiro, Brazil.
Jerson Lima da SilvaInstitute of Medical Biochemistry Leopoldo de Meis and National Institute of Science and Technology for Structural Biology and Bioimaging, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Rio de Janeiro, Brazil.
Leda CastilhoCell Culture Engineering Laboratory, COPPE, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Rio de Janeiro, Brazil.
Andréa Cheble de OliveiraInstitute of Medical Biochemistry Leopoldo de Meis and National Institute of Science and Technology for Structural Biology and Bioimaging, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Rio de Janeiro, Brazil.
Andre Marco de Oliveira GomesInstitute of Medical Biochemistry Leopoldo de Meis and National Institute of Science and Technology for Structural Biology and Bioimaging, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Rio de Janeiro, Brazil.ORCID 0000-0003-1052-8004
Marcelo Abrahão StrauchInstitute of Biological and Health Sciences, Department of Physiological Sciences, Federal Rural University of Rio de Janeiro, Seropedica, Brazil.

Funding

Brazilian Ministry of Science, Technology, and Innovation for Virus NetworkConselho Nacional de Desenvolvimento Científico e TecnológicoCoordenação de Aperfeiçoamento de Pessoal de Nível SuperiorFinanciadora de Estudos e ProjetosFundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
6 · The paper itself

Abstract

In this study, we aim to report the persistent presence of anti-SARS-CoV-2 immunoglobulins in pre-immunized mare offspring. Three mares from Vital Brazil Institute were pre-immunized with recombinant SARS-CoV-2 spike protein and became pregnant during this period. After parturition, the mares' serum and colostrum/milk and foal serum were collected over 6 weeks. Our results have shown high and persistent presence of IgG and neutralizing antibodies over the weeks not only in the mares' serum, as expected, but in mares' colostrum/milk and foal serum as well-what were very surprising. This peculiar approach, which we were able to track specifically antibodies produced from an antigen inoculated only in the pregnant mares', is distinct from the usual methodology applied in the current reports in this field. Thus, together, these data and our methodology could lead to new approaches to better understanding about equine passive immunization by newborn's breast-feeding.

Indexed as

Antibodies, NeutralizingAntibodies, ViralCOVID-19MilkSARS-CoV-2Spike Glycoprotein, CoronavirusAnimalsAnimals, NewbornColostrumFemaleHorsesImmunity, Maternally-AcquiredImmunizationImmunization, PassiveImmunoglobulin GPregnancyAntibodies, NeutralizingAntibodies, ViralImmunoglobulin GSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2foalsimmunoglobulin Gmarespassive immunizationSARS‐CoV‐2

Identifiers

PMID40699548
PMCPMC12285604

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.