Evidence map›Paper›PMID 40699525›Full record

SynthesisJournal of neuro-oncology2025

Stereotactic radiosurgery for intracranial and spinal adenoid cystic carcinoma: systematic review and illustrative case presentation.

Juan J Cardona, David J Park, Mohamed F Al Gharyani, Jen-Yeu Wang, Yusuke S Hori, Fred C Lam, Deya Abu-Reesh, Louisa Ustrzynski, Sara C Emrich, Armine Tayag and 3 more

Abstract readCase ReportsSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Journal of neuro-oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Juan J CardonaDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA, 94305, USA.
David J ParkDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA, 94305, USA. djpark@stanford.edu.
Mohamed F Al GharyaniDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Jen-Yeu WangDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Yusuke S HoriDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Fred C LamDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Deya Abu-ReeshDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Louisa UstrzynskiDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Sara C EmrichDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Armine TayagDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Gordon LiDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Melanie Hayden GephartDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Steven D ChangDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA, 94305, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAdenoid cystic carcinoma (ACC) is a rare, aggressive malignancy with a predilection for perineural spread and distant metastases. Given the limited but emerging evidence on the role of stereotactic radiosurgery (SRS) in managing intracranial and spinal ACC, a systematic review was deemed necessary to synthesize relevant parameters related to clinical features and management of ACC patients, SRS treatment characteristics, and clinical outcomes across published studies.

methodsThis systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A comprehensive search of the PubMed, Scopus, and Embase databases was performed to identify studies evaluating patients with histologically confirmed diagnoses of intracranial and/or spinal ACC who were treated with SRS. Additionally, a unique illustrative case was presented.

resultsA total of 129 patients and 211 lesions with ACC were identified from 16 studies published between 1992 and 2025. Patient ages ranged from 10 to 85 years. Lesions were mostly in the intracranial space (n = 194; 91.9%), followed by the spinal column (n = 17; 8.1%). Standalone SRS was administered as primary treatment in 108 lesions (57.1%). Six of eight studies documented a median prescription dose ≥ 15 Gy, while the mean calculated dose among case reports/series with individualized data was 20.8 Gy (SD = 10.4 Gy). Two of four studies recorded a median maximum tumor dose ≥ 30 Gy. Most treatment plans were delivered in a single fraction. Local tumor control (LTC) was achieved in 210/211 lesions (99.5%) over time, although 32/201 lesions eventually experienced local failure (15.9%). LTC duration ranged from 1 to 326 months, and overall survival ranged from 0 to 354 months. A 43-year-old male with concurrent intracranial and spinal ACC treated with CyberKnife SRS is presented.

conclusionsSRS offers favorable LTC for intracranial and spinal ACC, supporting its role as a precise, advanced radiation modality in this challenging context.

Indexed as

Brain NeoplasmsCarcinoma, Adenoid CysticRadiosurgerySpinal NeoplasmsAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedAdenoid cystic carcinoma; stereotactic radiosurgeryIntracranialLocal tumor controlOverall survivalSpinal

Identifiers

PMID40699525

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.