ArticleJournal of the Association for Research in Otolaryngology : JARO2025
Inhibition of Cortical Evoked Responses to Sound Pulses by Preceding Silent Gaps.
Article in Journal of the Association for Research in Otolaryngology : JARO, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Tinnitus.Nature reviews. Disease primers · 2026Review
- Article
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7 authors.
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Abstract
purposeThe basic principle of sensorimotor gating (SMG) relies on the ability of a weak lead stimulus (such as a pre-pulse) to inhibit a startling effect of a following, more intense, abrupt stimulus-the so-called pre-pulse inhibition (PPI) paradigm. PPI has been used for near half a century as a means to investigate psychiatric disorders in which its disruption is a surrogate for altered SMG in schizophrenia. However, the blinking response is very variable, making it a poor outcome measure at the individual level. Unlike PPI, which is regulated in the lateral globus pallidus from the basal ganglia, inhibition of the startle reflex by preceding silent gaps embedded in continuous background noise is processed in the auditory cortex, making it particularly suitable for measuring cortical responses.
methodsHere, based on the behavioral gap-pre-pulse inhibition of acoustic startle (GPIAS) stemming from animal research in tinnitus research, we present a new sensory gating (SG) paradigm using source-localized magnetoencephalography (MEG) in 26 normal hearing healthy participants (13 females, 12 males, 1 other) with a mean age of 28.4 (SD
resultsWe evidence a near 72.5% (SD
conclusionOverall, we provide evidence that SG, measured by N1 cortical response to sound pulses, is reliably inhibited by preceding gaps. We propose this paradigm as an effective method to assess auditory SG through development and aging, and potentially as a method for the diagnosis of hearing disorders like tinnitus or hyperacusis.
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