Evidence map›Paper›PMID 40699511›Full record

ArticleJournal of cardiovascular translational research2025

Enhancement of the Mayo Clinic HCM Genotype Predictor Score with Addition of Cardiac Magnetic Resonance Imaging.

Iuri Ferreira Felix, Vanessa Karlinski Vizentin, Mateo Alzate-Aguirre, Mehrie Patel, Jeffrey B Geske, Phillip Araoz, John R Giudicessi, Steve R Ommen, Adelaide M Arruda-Olson, Michael J Ackerman and 1 more

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in Journal of cardiovascular translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Iuri Ferreira FelixDepartment of Medicine, Mayo Clinic, Rochester, MN, USA.
Vanessa Karlinski VizentinDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
Mateo Alzate-AguirreDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
Mehrie PatelDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
Jeffrey B GeskeDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
Phillip AraozDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.
John R GiudicessiDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
Steve R OmmenDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
Adelaide M Arruda-OlsonDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
Michael J AckermanDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
J Martijn BosDepartment of Molecular Pharmacology and Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, Rochester, MN, USA. bos.martijn@mayo.edu.ORCID 0000-0002-3635-2003

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to evaluate the role of cardiac magnetic resonance (CMR) in updating The Mayo Clinic Hypertrophic Cardiomyopathy (HCM) Genotype Predictor Score. We performed an analysis of 175 HCM patients with an echocardiogram, CMR, and genetic test at the Mayo Clinic (2004 to 2018). Yield of a positive genetic test for the original echocardiogram-based score ranged from 38% (-1 point) to 100% (4 or 5 points), with an AUC of 0.659. Late gadolinium enhancement (LGE) presence was a strong predictor of positive genetic test (p = 0.002) and was added to the original score to create the updated version. The yield of positive genetic test for the updated score ranged from 25% (-1 point) to 100% (5 or 6 points) (p < 0.001), with an AUC of 0.724 and significant increase in diagnostic accuracy (p = 0.03). The updated genotype predictor score had improved accuracy when compared to the prior version.

Indexed as

Cardiomyopathy, HypertrophicDecision Support TechniquesGenetic TestingMagnetic Resonance Imaging, CineAdultAgedContrast MediaEchocardiographyFemaleGenetic Predisposition to DiseaseGenotypeHumansMaleMiddle AgedPhenotypePredictive Value of TestsContrast MediaCardiac magnetic resonanceGenetic testingGenotype predictorHypertrophic cardiomyopathy

Identifiers

PMID40699511

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.