Evidence map›Paper›PMID 40699490›Full record

ArticleSarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG2025

The Neutrophil-to-lymphocyte ratio as a diagnostic and prognostic biomarker in pulmonary hypertension: A systematic review.

Shokoufeh Khanzadeh, Sarina Aminizadeh, Shima Nourigheimasi, Brandon Lucke-Wold, Farid Rashidi, Cihangir Kaymaz, Pavel Janda, Abilio Reis, Michael Goutnik, Monireh Khanzadeh and 2 more

Abstract read
In one paragraph

Article in Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Shokoufeh KhanzadehDepartment of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Sarina AminizadehDepartment of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Shima NourigheimasiDepartment of Medicine, Arak University of Medical Sciences, Arak, Iran.ORCID 0000-0001-5038-8187
Brandon Lucke-WoldDepartment of Neurosurgery, University of Florida, Gainesville, USA.
Farid RashidiTuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Cihangir KaymazDepartment of Cardiology, Kosuyolu Heart Education and Research Hospital, University of Health Sciences, Istanbul, Turkey.
Pavel JandaDepartment of Cardiovascular Medicine, Charles University and General University Hospital, Prague, Czech Republic.
Abilio ReisDepartment of Medicine, Centro Hospitalar Universitario ´ do Porto, Porto, Portugal.
Michael GoutnikDepartment of Neurosurgery, University of Florida, Gainesville, USA.
Monireh KhanzadehGeriatric and Gerontology Department, Medical School, Tehran University of Medical sciences, Tehran, Iran.
Hamed Bazrafshan DrissiCardiovascular Department, Shiraz University of Medical Silences, Shiraz, Iran.
Fatemeh ChichagiTehran Heart Center, Tehran university of medical science, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe objective of this systematic review is to provide an overview of research that examined the relationship between pulmonary hypertension (PH) and the neutrophil-to-lymphocyte ratio (NLR).

methodsTo identify the studies related to NLR, a search was done on PubMed, Scopus, and Web of Science with an end date of  March 30th, 2023. A total of 25 studies were included in the review. These studies included a variety of pathologies that contribute to PH. We employed the Newcastle-Ottawa Scale to assess the quality of studies. For all studies, a significance level of P˂0.05 was used.

resultsIn patients with sarcoidosis, chronic obstructive pulmonary disease, systemic sclerosis, chronic kidney disease, and congenital heart disease, NLR appears to be an independent predictor of PH. Also, it was frequently linked to the result, complications, and severity of the disease in PH patients.

conclusionNLR may be utilized as a repeatable, inexpensive, and trustworthy proxy for the onset and severity of PH.

Identifiers

PMID40699490
PMCPMC12242872

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.