Evidence map›Paper›PMID 40699414›Full record

Observational studyInternational urology and nephrology2026

The prognostic role of hemoglobin, albumin, lymphocyte, and platelets score in peritoneal dialysis.

Xiaoyu Guo, Panai Song, Yijin Qian, Ning Zhuo, Xiaohui Fu, Yinghong Liu

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in International urology and nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Xiaoyu GuoDepartment of Nephrology and Blood Purification Center, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Panai SongDepartment of Nephrology and Blood Purification Center, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Yijin QianDepartment of Pulmonary and Critical Care Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Ning ZhuoDepartment of Nephrology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, China.
Xiaohui FuDepartment of Nephrology and Blood Purification Center, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Yinghong LiuDepartment of Nephrology and Blood Purification Center, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China. liuyingh2002@csu.edu.cn.

Funding

the Changsha Municipal Natural Science Foundation kq2202401 and kq2014235the Natural Science Foundation of Hunan Province 2022JJ30835 and 2021JJ30942
6 · The paper itself

Abstract

backgroundThe Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) index serves as a novel composite biomarker reflecting both systemic inflammation and nutritional status in clinical practice.

methodsThis observational cohort study enrolled 892 peritoneal dialysis patients categorized by HALP quartiles (Q1-Q4). Through comprehensive survival analyses including Kaplan-Meier curves and multivariable Cox regression, we systematically evaluated the prognostic value of HALP for mortality outcomes. Predictive performance was rigorously assessed using time-dependent receiver operating characteristic analysis and net reclassification improvement metrics.

resultsThe analysis revealed clinically significant findings where patients in the highest HALP quartile demonstrated markedly better survival outcomes compared to the lowest quartile, with hazard ratios of 0.43 (95% CI 0.21-0.86) for all-cause mortality and 0.23 (95% CI 0.08-0.69) for cardiovascular mortality. Importantly, incorporating HALP into prediction models yielded meaningful clinical improvements, elevating the 5-year mortality prediction accuracy from an AUC and achieving a statistically significant net reclassification improvement of 15%.

conclusionsThese findings establish HALP as a practical and robust prognostic indicator in peritoneal dialysis patients that not only independently predicts mortality risk but also provides substantial incremental value beyond conventional risk factors, offering potential clinical utility for risk stratification and patient management decisions.

Indexed as

HemoglobinsKidney Failure, ChronicPeritoneal DialysisSerum AlbuminAgedBiomarkersBlood PlateletsCohort StudiesFemaleHumansLymphocyte CountLymphocytesMaleMiddle AgedPlatelet CountPrognosisBiomarkersHemoglobinsSerum AlbuminAlbuminHemoglobinLymphocytePeritoneal dialysisPlateletsPrognosis

Identifiers

PMID40699414

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.