Evidence map›Paper›PMID 40699407›Full record

ArticleEJNMMI research2025

Association of white matter injury and neuroinflammation in the post-acute phase after ischemic stroke using [

Stefan E Poirier, Rachel Wagner, Linshan Liu, Pavlo Ohorodnyk, Michael T Jurkiewicz, Alexander Thiel, Jonathan D Thiessen, Alexander V Khaw, Udunna C Anazodo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EJNMMI research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Stefan E PoirierLawson Health Research Institute, London, ON, Canada. spoirie6@uwo.ca.ORCID http://orcid.org/0000-0002-0666-7952
Rachel WagnerSchool of Medicine, Queen's University, Kingston, ON, Canada.
Linshan LiuLawson Health Research Institute, London, ON, Canada.
Pavlo OhorodnykDepartment of Medical Imaging, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Michael T JurkiewiczDepartment of Medical Imaging, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Alexander ThielDepartment of Neurology and Neurosurgery, Jewish General Hospital, McGill University, Montréal, QC, Canada.
Jonathan D ThiessenLawson Health Research Institute, London, ON, Canada.
Alexander V Khaw *Lawson Health Research Institute, London, ON, Canada.
Udunna C Anazodo *Lawson Health Research Institute, London, ON, Canada. udunna.anazodo@mcgill.ca.

Funding

CIHR Canadian Institutes of Health ResearchHeart and Stroke Foundation of Canada Heart and Stroke Foundation of CanadaLawson Health Research Institute Lawson Health Research InstituteMax-Planck-Gesellschaft Max-Planck-Gesellschaft
6 · The paper itself

Abstract

backgroundCerebral white matter (WM) injury after ischemic stroke is associated with post-stroke cognitive impairment (PSCI), however, the interaction between sustained neuroinflammation and post-stroke WM injury is not well understood. Hybrid PET/MRI can provide insight into pathophysiological mechanisms linking chronic neuroinflammation, ischemic WM injury, and PSCI. Using PET/MRI, this study investigated the relationship between [

results[

conclusionsThis study found an association between elevated post-acute glial activation (neuroinflammation) and reduced microstructure integrity in brain WM pathways ipsilateral to ischemic infarcts and remote from WM lesions at 6-months post-stroke. Hybrid PET/MRI is promising to be a valuable tool for probing post-acute neuroinflammation and associated changes in cerebral WM pathways following ischemic stroke.

Indexed as

[18F]FEPPADiffusion tensor imagingNeuroinflammationPET/MRIStrokeWhite matter

Identifiers

PMID40699407
PMCPMC12287493

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.