SynthesisWorld journal of urology2025
Association between preoperative serum testosterone levels and the risk of postoperative erectile function after nerve-sparing radical prostatectomy: a systematic review and meta-analysis.
Synthesis in World journal of urology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundThe predictive value of preoperative testosterone levels for erectile function (ED) preservation after nerve-sparing radical prostatectomy (NSRP) remains controversial, with conflicting evidence regarding its clinical utility for surgical planning and patient counseling.
methodsComprehensive searches of MEDLINE, Cochrane Library, and Embase were conducted through May 1, 2025. Observational studies reporting adjusted odds ratios (ORs) with 95% confidence intervals (CIs) for postoperative ED stratified by preoperative testosterone levels were included. Random-effects models were used for meta-analysis, with subgroup analyses by study design and surgical approach. Outcomes included postoperative erectile function status assessed via validated questionnaires or clinical evaluations at ≥ 6-month follow-up.
resultsFour cohort studies involving 2,312 patients were included in the meta-analysis. Pooled analysis demonstrated significantly increased ED risk with lower preoperative testosterone levels (OR = 1.72, 95%CI: 1.26-2.35; P = 0.001; I
conclusionCurrent evidence demonstrates that low preoperative serum testosterone levels significantly increase the risk of ED following NSRP. Furthermore, preoperative testosterone assessment enables urologists to implement standardized postoperative management protocols, including targeted rehabilitation strategies and optimized follow-up schedules for high-risk patients.
Indexed as
Identifiers
40699366What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.