ArticleArchives of orthopaedic and trauma surgery2025
The sole use of stem cells in treating fracture nonunion: a scoping review.
Article in Archives of orthopaedic and trauma surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Biological Augmentation of Reamed Intramedullary Nailing for Aseptic Tibial Shaft Nonunion: An Exploratory Multicenter Retrospective Comparative Cohort Study.Journal of functional morphology and kinesiology · 2026Article
- Intradermal Application of Allogenic Wharton's Jelly Mesenchymal Stem Cells for Chronic Post-Thoracotomy Wound in an Elderly Patient After Coronary Artery Bypass Grafting: Clinical Case with Brief Literature Review.Diseases (Basel, Switzerland) · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objective of this studyThis scoping-review aims to highlight the current modalities of sole use of stem cells in treating fracture nonunion updating a previous systematic review from 2013. We report solitary stem cell stimulation in literature in vivo studies to obtain current knowledge in understanding the crucial role of stem cells in enhancing fracture nonunion healing. MATERIALS AND
methodsThis scoping review was conducted by systematical search in PubMed, Medline and clinicaltrials.gov with a timeframe from October 2012 to September 2024. Two authors independently screened all articles, and when included, the following information was extracted: type of nonunion, localization, type of stem cells, administered dose of stem cells, surgical information, type of scaffold, control group, evaluation method, time of evaluation post intervention, and adverse events.
resultsOf 4710 articles screened, 27 articles met the criteria for inclusion. In the reviewed articles, 2 out of 5 human studies, and 8 out of 12 animal studies with a control group reported a statistically significant effect of stem cells on bone healing when used in the treatment of fracture nonunion. Comparison of the studies was difficult due to heterogeneity. The administration of mesenchymal stem cells regarding adverse events was investigated in eight human studies.
conclusionBased on our reporting, the articles suggest that the perspectives of the sole use of mesenchymal stem cells in the management of fracture nonunion might be promising but remain inconclusive. Future research should be inspired by existing literature and focus on the development of well-standardized methodologies and results published.
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