Evidence map›Paper›PMID 40699330›Full record

ArticlePediatric surgery international2025

Intraoperative quantitative analysis of intestinal perfusion by ICG fluorescence in Hirschsprung disease: a single-center retrospective cohort study.

Zhen Zhang, Ya Gao, Ya Ma, Ruijie Zhou, Yong Chen, Long Li, Qian Jiang, Qi Li

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Article in Pediatric surgery international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhen Zhang *Department of General Surgery, Capital Center for Children's Health, Capital Medical University, No. 2 Yabao Rd., Chaoyang District, Beijing, 100020, China.
Ya Gao *Department of Medical Genetics, Capital Institute of Pediatrics, Beijing, 100020, China.
Ya MaDepartment of Ultrasound, Capital Center for Children's Health, Capital Medical University, Beijing, 100020, China.
Ruijie ZhouDepartment of General Surgery, Capital Center for Children's Health, Capital Medical University, No. 2 Yabao Rd., Chaoyang District, Beijing, 100020, China.
Yong ChenDepartment of Pediatric Surgery, KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore, 229899, Singapore.
Long LiDepartment of General Surgery, Capital Center for Children's Health, Capital Medical University, No. 2 Yabao Rd., Chaoyang District, Beijing, 100020, China.
Qian JiangDepartment of Medical Genetics, Capital Institute of Pediatrics, Beijing, 100020, China. jiangqian@pumc.edu.cn.
Qi LiDepartment of General Surgery, Capital Center for Children's Health, Capital Medical University, No. 2 Yabao Rd., Chaoyang District, Beijing, 100020, China. l817@sina.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivePostoperative complications at the coloanal anastomosis site following surgery for Hirschsprung disease (HSCR) can significantly impact bowel function recovery in children. Indocyanine green (ICG) fluorescence imaging provides a real-time, quantitative assessment of perfusion, potentially improving surgical outcomes. This study aims to evaluate the effectiveness of an ICG-based quantitative perfusion analysis strategy compared to conventional visual assessment in determining anastomotic site selection.

methodsThis single-center retrospective study included consecutive patients with histologically confirmed HSCR who underwent surgery between January 2023 and January 2024. Following vascular arcade ligation and transanal pull-through, anastomotic site selection was guided either by conventional visual assessment (Visual Group) or ICG fluorescence angiography with quantitative perfusion analysis (ICG Group). We chose the specific ICG perfusion parameters (Fmax > 30 AU, Tmax < 30 s) as safe anastomotic site thresholds. Postoperative complications, functional outcome and perianal ultrasound findings were assessed during follow-up.

resultsA total of 167 patients were included, with 34 in the ICG Group and 133 in the Visual Group. Both groups had comparable baseline characteristics. While no significant differences were observed in postoperative bowel movement recovery or major anastomotic complications, perianal ultrasound at 5-7 days postoperatively revealed significantly reduced anastomotic inflammation in the ICG Group. Follow-up analysis showed that the ICG Group had a shorter hospital stay (7 days, IQR 7-8 vs. 8 days, IQR 7-10.5, p = 0.003), as well as a higher percentage of HAEC-free patients (78.1% for ICG vs. 56.8% for Visual) compared to the Visual Group.

conclusionQuantitative ICG fluorescence imaging provides a more precise and objective approach for anastomotic site selection in HSCR surgery. This strategy may reduce postoperative anastomotic inflammation and HAEC. Further studies are needed to validate its long-term clinical benefits and establish standardized protocols for pediatric colorectal surgery.

Indexed as

ColonFluorescein AngiographyHirschsprung DiseaseIndocyanine GreenAnastomosis, SurgicalChildChild, PreschoolFemaleHumansInfantMalePostoperative ComplicationsRetrospective StudiesIndocyanine GreenAnastomotic complicationsHirschsprung diseaseIndocyanine green fluorescence imagingQuantitative perfusion analysis

Identifiers

PMID40699330

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.