ArticleAbdominal radiology (New York)2026
Contrast-enhanced CT-derived extracellular volume fraction in preoperative prediction of tumor-stroma ratio in colorectal cancer.
Article in Abdominal radiology (New York), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Performance of dual-layer spectral CT-based extracellular volume fraction to assess Ki-67 proliferation status in rectal cancer: comparison with diffusion kurtosis imaging.Insights into imaging · 2026Article
- Delayed phase dual-energy CT for early peritoneal metastasis prediction: imaging phenotypes and tumor-stroma correlates in upfront gastrectomy candidates.Abdominal radiology (New York) · 2026Article
- Application value of CT-based extracellular volume fraction in assessing microsatellite status in colorectal cancer.American journal of translational research · 2026Article
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10 authors.
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Abstract
objectivesThis study aimed to investigate the value of contrast-enhanced computed tomography (CECT)-derived extracellular volume (ECV) fraction for preoperative evaluation of tumor-stroma ratio (TSR) in colorectal cancer (CRC). MATERIALS AND
methodsWe retrospectively analyzed CRC patients who underwent CECT between July 2021 and July 2023. Patients were randomly allocated into a training cohort (n = 188) and a validation cohort (n = 78). Based on histopathological TSR score, patients were stratified into high-TSR (stroma proportion > 50%) and low-TSR (stroma proportion ≤ 50%) groups. Clinical characteristics and CECT parameters were compared and analyzed. Logistic regression analysis was conducted on the training cohort to identify independent predictors for high TSR. Predictive performance was assessed using receiver operating characteristic (ROC) curves, with area under the curve (AUC) differences compared using the Delong test.
resultsIn the training cohort, the high-TSR group showed significantly lower non-contrast CT value (CTpre) but higher equilibrium phase CT value (CT EP), the difference between venous phase CT value and CTpre (D-value), arterial phase CT enhancement rate (CER), and ECV fraction (all P < 0.05). The ECV fraction demonstrated the highest predictive performance (AUC = 0.808, 95% confidence interval [CI]: 0.745-0.872). CT EP and ECV fraction were identified as independent predictors for high TSR. A model combining ECV fraction and CT EP yielded AUCs of 0.811 (95% CI: 0.748-0.874) and 0.733 (95% CI: 0.623-0.843) in the training and validation cohorts, respectively, with no significant differences compared to the ECV fraction alone (all P > 0.05).
conclusionsThe ECV fraction serves as a reliable CECT biomarker for preoperative high TSR prediction in CRC, showing potential for noninvasive stroma evaluation and guiding individualized therapeutic strategies.
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