Evidence map›Paper›PMID 40699237›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2026

Chlorpromazine induces hyposalivation by inhibiting muscarinic Ca

Yoon-Jung Kim, Yoo-Bin Kim, Soohyun Kim, Tae-Yong Choi, Hee-Kyung Park, Se-Young Choi

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07720466 (Prospective Evaluation of Salivary Calcium Levels, Salivary Function, and Dental Hard Tissue Changes in Patients Receiving GLP-1 Receptor Agonist Therapy), which is not on this map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07720466 not yet recruitingnot on this map

Prospective Evaluation of Salivary Calcium Levels, Salivary Function, and Dental Hard Tissue Changes in Patients Receiving GLP-1 Receptor Agonist Therapy

TypeobservationalSponsorBilecik Seyh Edebali UniversitesiRan2026 to 2027Enrolled40ConditionsObesity, Dental Erosion, Saliva Collection, Saliva AlteredArmsUnstimulated Whole Saliva Collection, Salivary Analysis, Oral Examination and BEWE Assessment, Standardized Intraoral Photography
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yoon-Jung Kim *Department of Physiology, Dental Research Institute, Seoul National University School of Dentistry, Seoul, 03080, Republic of Korea.
Yoo-Bin Kim *Department of Physiology, Dental Research Institute, Seoul National University School of Dentistry, Seoul, 03080, Republic of Korea.
Soohyun KimDepartment of Physiology, Dental Research Institute, Seoul National University School of Dentistry, Seoul, 03080, Republic of Korea.
Tae-Yong ChoiDepartment of Physiology, Dental Research Institute, Seoul National University School of Dentistry, Seoul, 03080, Republic of Korea.
Hee-Kyung ParkDepartment of Oral Medicine and Oral Diagnosis, Dental Research Institute, Seoul National University School of Dentistry, Seoul, 03080, Republic of Korea. dentopark@snu.ac.kr.
Se-Young ChoiDepartment of Physiology, Dental Research Institute, Seoul National University School of Dentistry, Seoul, 03080, Republic of Korea. sychoi@snu.ac.kr.

Funding

National Research Foundation of Korea 2018R1A5A2024418National Research Foundation of Korea 2021R1A2C2005573National Research Foundation of Korea 2021R1C1C2011217
6 · The paper itself

Abstract

Chlorpromazine (CPZ), a dopamine D2 receptor antagonist, is an antipsychotic drug widely used in the treatment of schizophrenia. While CPZ is known to induce hyposalivation, the exact mechanism by which it inhibits secretory function in the salivary glands remains unclear. In this study, we investigated the molecular mechanism underlying CPZ-induced hyposalivation. Our findings confirmed that CPZ decreases salivation by inhibiting muscarinic signaling in a dose-dependent manner in a mouse model. By analyzing a single-cell RNA sequencing (scRNA-seq) database, we searched known CPZ targets in salivary gland cells and found that dopamine receptors are not expressed in these cells. CPZ inhibited the increase in intracellular Ca

Indexed as

Antipsychotic AgentsCalcium SignalingChlorpromazineDopamine D2 Receptor AntagonistsReceptors, MuscarinicSalivary GlandsSalivationXerostomiaAnimalsCalciumDose-Response Relationship, DrugHumansMaleMiceMice, Inbred C57BLAntipsychotic AgentsCalciumChlorpromazineDopamine D2 Receptor AntagonistsReceptors, MuscarinicChlorpromazineG-protein–coupled receptorHyposalivationIntracellular Ca2+Salivary glandStore-operated Ca2+ entry

Identifiers

PMID40699237
PMCPMC12894136

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.