Evidence map›Paper›PMID 40699227›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2025

Evaluation of inflammatory markers in pediatric patients with otitis media with effusion: a retrospective analysis.

Agah Yeniceri, Cetin Sahutoglu, Ibrahim Sevim, Melih Cayonu

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Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Inflammatory markers as determinants of glue-type effusion and recurrent ventilation tube placement.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Agah YeniceriDepartment of Otorhinolaryngology, University of Health Science, Ankara Bilkent City Hospital, Universiteler Neighborhood 1604thStreet No.9, Ankara, 06800, Turkey. agahyeniceri@gmail.com.ORCID http://orcid.org/0000-0002-5024-4009
Cetin SahutogluDepartment of Otorhinolaryngology, University of Health Science, Ankara Bilkent City Hospital, Universiteler Neighborhood 1604thStreet No.9, Ankara, 06800, Turkey.ORCID http://orcid.org/0009-0002-0870-331X
Ibrahim SevimDepartment of Otorhinolaryngology, University of Health Science, Ankara Bilkent City Hospital, Universiteler Neighborhood 1604thStreet No.9, Ankara, 06800, Turkey.ORCID http://orcid.org/0009-0001-5180-520X
Melih CayonuDepartment of Otorhinolaryngology, University of Health Science, Ankara Bilkent City Hospital, Universiteler Neighborhood 1604thStreet No.9, Ankara, 06800, Turkey.ORCID http://orcid.org/0000-0001-5542-1898

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeOtitis media with effusion (OME) is a common pediatric condition associated with hearing loss and reduced quality of life. This study aims to evaluate the clinical significance of various inflammatory markers in pediatric OME patients who have undergone surgical treatment.

methodsA retrospective analysis was conducted on 1,121 pediatric patients aged 2-15 years, including 613 OME patients who underwent tympanostomy tube placement (with or without adenoidectomy) and 508 healthy controls. Complete blood count parameters were recorded. Patients were divided into two groups based on the viscosity of intraoperative middle ear effusion as serous or mucoid and graded according to their adenoid sizes. Comparisons between groups were analyzed using appropriate statistical methods.

resultsThere was a significant difference in %LUC, SII, SIRI, and MLR values between the OME patients and the control group (p < 0.05). SII, SIRI, and MLR values were higher in the OME patient group, whereas %LUC was higher in the control group. ROC analysis did not yield significant cut-off values for any marker. Among adenoid grade groups, only %LUC showed a statistically significant difference (p = 0.018). There was no significant relationship between the viscosity of middle ear effusion and any of the inflammatory markers.

conclusionThe data suggest that inflammatory markers may be associated with OME; however, their clinical utility remains uncertain. Further prospective studies are needed to evaluate their potential role in the diagnosis and follow-up of at-risk pediatric patients.

Indexed as

Otitis Media with EffusionAdenoidectomyAdenoidsAdolescentBiomarkersCase-Control StudiesChildChild, PreschoolFemaleHumansMaleMiddle Ear VentilationRetrospective StudiesBiomarkersAdenoid hypertrophyİnflammatory markersMiddle ear effusionOtitis media with effusionViscosity

Identifiers

PMID40699227

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.