Evidence map›Paper›PMID 40699144›Full record

ArticleBiochemistry2025

The ERVK3-1 Microprotein Interacts with the HUSH Complex.

Ayodya Jayatissa, Nadiya Jaunbocus, Betel Erkalo, Kevin Jiang, Shu-Jian Zheng, Haomiao Su, Lichong Yan, Jin-Young Choi, Joan Vaughan, Antonella Bacchiocchi and 7 more

Abstract read
In one paragraph

Article in Biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Ayodya JayatissaDepartment of Chemistry, Yale University, New Haven, Connecticut 06520, United States.
Nadiya JaunbocusDepartment of Chemistry, Yale University, New Haven, Connecticut 06520, United States.
Betel ErkaloDepartment of Chemistry, Yale University, New Haven, Connecticut 06520, United States.
Kevin JiangDepartment of Chemistry, Yale University, New Haven, Connecticut 06520, United States.
Shu-Jian ZhengDepartment of Chemistry, Yale University, New Haven, Connecticut 06520, United States.
Haomiao SuDepartment of Chemistry, Yale University, New Haven, Connecticut 06520, United States.ORCID 0000-0001-6232-6725
Lichong YanDepartment of Immunobiology, Yale School of Medicine, New Haven, Connecticut 06510, United States.
Jin-Young ChoiSection of Rheumatology, Allergy and Immunology, Department of Medicine, Yale School of Medicine, New Haven, Connecticut 06510, United States.
Joan VaughanClayton Foundation Peptide Biology Laboratories, The Salk Institute for Biological Studies, La Jolla, California 92037, United States.
Antonella BacchiocchiDepartment of Dermatology, Yale School of Medicine, New Haven, Connecticut 06510, United States.
Zhenkun NaDepartment of Chemistry, Yale University, New Haven, Connecticut 06520, United States.
Xiongwen CaoDepartment of Chemistry, Yale University, New Haven, Connecticut 06520, United States.
Ruth HalabanDepartment of Dermatology, Yale School of Medicine, New Haven, Connecticut 06510, United States.
Alan SaghatelianClayton Foundation Peptide Biology Laboratories, The Salk Institute for Biological Studies, La Jolla, California 92037, United States.ORCID 0000-0002-0427-563X
Joseph CraftDepartment of Immunobiology, Yale School of Medicine, New Haven, Connecticut 06510, United States.
Y Grace ChenDepartment of Immunobiology, Yale School of Medicine, New Haven, Connecticut 06510, United States.
Sarah A SlavoffDepartment of Chemistry, Yale University, New Haven, Connecticut 06520, United States.ORCID 0000-0002-4443-2070

Funding

Yale SPORE in Skin CancerP50CA121974 · NCI · YALE UNIVERSITY · PI MARCUS W BOSENBERG, Harriet M. Kluger · 2006 to 2026
$43.9M
IMMUNE RESPONSES IN LUPUSR37AR040072 · NIAMS · YALE UNIVERSITY · PI CRAFT, JOSEPH EDGAR · 2000 to 2025
$7.4M
The Regulation of Circular RNA FunctionsR35GM142687 · NIGMS · YALE UNIVERSITY · PI CHEN, YE GRACE · 2021 to 2025
$2.2M
Translation of overprinted non-canonical open reading frames from alternative transcript variantsR01GM155404 · NIGMS · YALE UNIVERSITY · PI Sarah Ann Slavoff · 2024 to 2026
$1.3M
NCI NIH HHS P50 CA121974NIAMS NIH HHS R37 AR040072NIGMS NIH HHS R01 GM155404NIGMS NIH HHS R35 GM142687
6 · The paper itself

Abstract

Human endogenous retroviruses (hERVs) are noninfectious molecular remnants of ancient exogenous retroviruses that now make up 8% of the human genome. The ubiquitously expressed human

Indexed as

Endogenous RetrovirusesHEK293 CellsHeLa CellsHumansProtein Binding

Identifiers

PMID40699144
PMCPMC12339190

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.