ArticlemSystems2025
A new era in gammaherpesvirus transcriptomics: high-resolution profiling and model development.
Article in mSystems, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Veterinary Herpesviruses: Experimental Tools for Transcriptomics and Neuroscience.Veterinary sciences · 2026Review
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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A recent article by Torma et al. (G. Torma, Á. Dörmő, Á. Fülöp, D. Tombácz, et al., mSystems 10:e01678-24, 2025, https://doi.org/10.1128/msystems.01678-24) presents the first high-resolution, long-read transcriptomic atlas of Caviid gammaherpesvirus 1 (CaGHV-1), offering insights into its transcriptional complexity. Using nanopore direct RNA and cDNA sequencing, the study maps transcription start sites, polyadenylation signals, alternative splicing, and upstream open reading frames (uORFs), revealing a landscape of coding and non-coding RNAs with pervasive transcriptional overlaps. These features underscore the evolutionary conservation of key regulatory mechanisms across gammaherpesviruses, notably replication and transcription activator (RTA)-mediated transcriptional control. By establishing CaGHV-1 as a promising model for Kaposi's sarcoma-associated herpesvirus (KSHV)-related disease, the work sets a foundation for studies of viral gene regulation, immune evasion, and pathogenesis, including bacterial artificial chromosomes (BACs) for genetic manipulation. Here, we discuss the advances in the study as well as how some limitations remain regarding read coverage biases, sequencing errors, and the uncharacterized functions of non-coding RNAs and emphasize the need for validation and functional assays. This study provides a valuable resource for understanding gammaherpesvirus biology and advancing translational research in viral pathogenesis and therapeutic development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.