Evidence map›Paper›PMID 40698943›Full record

ArticleMicrobiology spectrum2025

Analysis of Fc-dependent effector functions of anti-malaria circumsporozoite protein antibodies.

Erin Stefanutti, Rashmi Ramani, Bradley Whitener, Ha Dang, Simon Bélanger, Logeshwaran Somasundaram, Karen Cortina, Anna De Marco, Tommy Tam, Qingqing Chai and 7 more

Abstract read
In one paragraph

Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Erin Stefanutti *Vir Biotechnology, San Francisco, California, USA.
Rashmi Ramani *Vir Biotechnology, San Francisco, California, USA.
Bradley Whitener *Vir Biotechnology, San Francisco, California, USA.
Ha Dang *Vir Biotechnology, San Francisco, California, USA.
Simon BélangerVir Biotechnology, San Francisco, California, USA.
Logeshwaran SomasundaramVir Biotechnology, San Francisco, California, USA.
Karen CortinaVir Biotechnology, San Francisco, California, USA.
Anna De MarcoVir Biotechnology, Bellinzona, Switzerland.
Tommy TamVir Biotechnology, San Francisco, California, USA.
Qingqing ChaiVir Biotechnology, San Francisco, California, USA.
Elisabetta CameroniVir Biotechnology, Bellinzona, Switzerland.
Rajesh GuptaVir Biotechnology, San Francisco, California, USA.
Michael A SchmidVir Biotechnology, Bellinzona, Switzerland.
Jessica L MillerVir Biotechnology, San Francisco, California, USA.ORCID 0000-0001-6080-6143
Anna Brotcke Zumsteg *Vir Biotechnology, San Francisco, California, USA.
Lisa A Purcell *Vir Biotechnology, San Francisco, California, USA.
Lisa L Drewry *Vir Biotechnology, San Francisco, California, USA.ORCID 0000-0003-2208-9010

Funding

Gates Foundation INV-033423
6 · The paper itself

Abstract

Antibodies targeting the malaria circumsporozoite protein (CSP) can prophylactically protect against malaria by targeting

Indexed as

Antibodies, MonoclonalAntibodies, ProtozoanImmunoglobulin Fc FragmentsMalariaProtozoan ProteinsAnimalsFemaleHumansKiller Cells, NaturalMiceMice, Inbred C57BLPhagocytosisPlasmodium falciparumAntibodies, MonoclonalAntibodies, Protozoancircumsporozoite protein, ProtozoanImmunoglobulin Fc FragmentsProtozoan Proteinsantibody functionsantimalarial agentseffector functionsmalariamonoclonal antibodies

Identifiers

PMID40698943
PMCPMC12403835

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.