Evidence map›Paper›PMID 40698858›Full record

Observational studyPM & R : the journal of injury, function, and rehabilitation2026

Impact of COVID-19 positive status on outcome for individuals with stroke treated in acute inpatient rehabilitation.

Amy Ziems, Christopher J McLouth, Nicholas Elwert, Elissa Charbonneau, Joseph Stillo, Susan McDowell

Abstract readObservational StudyMulticenter Study
In one paragraph

Observational study in PM & R : the journal of injury, function, and rehabilitation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Amy ZiemsFellow, Brian Injury Medicine, Physical Medicine and Rehabilitation, University of Kentucky, Lexington, Kentucky, USA.
Christopher J McLouthDepartment of Biostatistics, University of Kentucky, Lexington, Kentucky, USA.
Nicholas ElwertPhysical Medicine and Rehabilitation, University of Kentucky, Lexington, Kentucky, USA.ORCID 0000-0002-3642-7474
Elissa CharbonneauPhysical Medicine and Rehabilitation, Tufts University Medical School, Boston, Massachusetts, USA.
Joseph StilloPhysical Medicine and Rehabilitation, Encompass Health Corp, Birmingham, Alabama, USA.ORCID 0000-0001-7493-3936
Susan McDowellPhysical Medicine and Rehabilitation, University of Kentucky, Lexington, Kentucky, USA.ORCID 0009-0005-5317-3591

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStroke, whether or not accompanied by concurrent COVID-19 infection, has been associated with varying acute care outcomes, with patients who are COVID-19 positive typically faring worse. This study aims to explore the functional outcomes of patients with stroke -with and without simultaneous COVID-19 infection-who survived their acute care stay and progressed to acute inpatient rehabilitation (IRF).

objectivesTo identify differences in sociodemographic factors, medical complexity, and rehabilitation outcomes from an IRF stay between patients with stroke with concurrent COVID-19 and those without.

designA retrospective, observational cohort study using electronic medical records (EMR) data.

settingEMR data from 138 IRFs across 34 states of the United States and Puerto Rico involving 40,282 individuals following stroke discharged between April 1, 2020 and May 31, 2021 of whom 1483 (3.7%) were COVID-19 positive.

participantsNA.

interventionsNA.

main outcome measuresVariables collected included sociodemographic and medical complexity along with outcome variable categories included functional complexity, process outcomes, and functional abilities.

resultsSignificant differences were found between the two groups using standardized effect sizes >0.2. COVID-19 positive patients with stroke had more comorbidities (94.1% vs. 51.8%, standardized effect = 1.1), lower admission mobility (26 vs. 30, standardized effect = 0.27), lower discharge mobility scores (56 vs. 65, standardized effect = 0.27), and a longer IRF stay (17 days vs. 14 days, standardized effect = 0.30). They also were less likely to return to the community (65.5% vs. 78.3%) but had a higher acute care transfer rate (19.1% vs. 10.6%). Logistic regression showed that Hispanic COVID-positive individuals and those with higher mobility scores were more likely to be discharged to the community.

conclusionsThere are meaningful differences in rehabilitation outcomes between COVID-19 positive and negative individuals with stroke that clinicians can use to better understand, anticipate and mitigate outcome challenges facing the COVID-19 positive population with stroke.

Indexed as

COVID-19StrokeStroke RehabilitationAgedFemaleHumansInpatientsMaleMiddle AgedRetrospective StudiesSARS-CoV-2United States

Identifiers

PMID40698858
PMCPMC12828636

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.