Evidence map›Paper›PMID 40698819›Full record

ArticleAntimicrobial agents and chemotherapy2025

Mutations in transcription factors that confer fluconazole resistance also confer reduced susceptibility to manogepix in

Katherine S Barker, Hoja P Patterson, Joachim Morschhäuser, Christina A Cuomo, Nathan P Wiederhold, P David Rogers

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Review
  3. New Perspectives on Antimicrobial Agents: Fosmanogepix.Antimicrobial agents and chemotherapy · 2026
    Review
  4. Deciphering the multidrug resistance paradigm inAntimicrobial agents and chemotherapy · 2026
    Review
  5. Article
  6. Genomic Insights intoJournal of fungi (Basel, Switzerland) · 2026
    Article
  7. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Katherine S BarkerDepartment of Pharmacy and Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, Tennessee, USA.ORCID 0000-0002-3824-6829
Hoja P PattersonDepartment of Pathology and Laboratory Medicine, Fungus Testing Laboratory, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Joachim MorschhäuserInstitute of Molecular Infection Biology, University of Würzburg, Würzburg, Bavaria, Germany.ORCID 0000-0003-4227-8687
Christina A CuomoDepartment of Molecular Microbiology and Immunology, Brown University, Providence, Rhode Island, USA.
Nathan P WiederholdDepartment of Pathology and Laboratory Medicine, Fungus Testing Laboratory, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.ORCID 0000-0002-2225-5122
P David RogersDepartment of Pharmacy and Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, Tennessee, USA.ORCID 0000-0002-4401-0679

Funding

Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Shondra Michelle Miller · 1985 to 2026
$166.9M
Mapping the genomic and molecular mechanisms of antifungal resistance in the emerging fungal pathogen Candida aurisR01AI169066 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Christina A Cuomo, P. David Rogers · 2023 to 2026
$4.9M
NCI NIH HHS P30 CA021765NIAID NIH HHS R01 AI169066NIH HHS R01 AI169066
6 · The paper itself

Abstract

The fungal pathogen

Indexed as

Antifungal AgentsCandidaCandida albicansCandida aurisCandida glabrataCandida parapsilosisDrug Resistance, FungalFluconazoleTranscription FactorsATP-Binding Cassette TransportersCandidiasisFungal ProteinsMembrane Transport ProteinsMicrobial Sensitivity TestsMutationAntifungal AgentsATP-Binding Cassette TransportersCDR1 protein, Candida albicansFluconazoleFungal ProteinsMembrane Transport ProteinsTranscription FactorsCandida albicansCandida aurisCandida glabrataCandida parapsilosisfluconazolemanogepix

Identifiers

PMID40698819
PMCPMC12406679

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.