Evidence map›Paper›PMID 40698814›Full record

ArticleAntimicrobial agents and chemotherapy2025

VH3810109 (N6LS) broadly neutralizing antibody safety, pharmacokinetics, and anti-drug antibody incidence in adults without HIV: phase 1 SPAN study results.

Peter A Leone, Jan Losos, Paul Wannamaker, Riccardo D'Agostino, Michael Warwick-Sanders, Gabriela L Ghita, Viviana Wilches, Christina Donatti, Kathryn Brown, Yash Gandhi

Abstract readClinical Trial, Phase I
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Peter A LeoneViiV Healthcare, Durham, North Carolina, USA.ORCID 0009-0003-6012-091X
Jan LososViiV Healthcare, Durham, North Carolina, USA.
Paul WannamakerViiV Healthcare, Durham, North Carolina, USA.
Riccardo D'AgostinoGSK, London, United Kingdom.
Michael Warwick-SandersGSK, London, United Kingdom.
Gabriela L GhitaGSK, Collegeville, Pennsylvania, USA.
Viviana WilchesGSK, Collegeville, Pennsylvania, USA.
Christina DonattiViiV Healthcare, London, United Kingdom.
Kathryn BrownCertara, Radnor, Pennsylvania, USA.
Yash GandhiGSK, Collegeville, Pennsylvania, USA.

Funding

ViiV Healthcare NA
6 · The paper itself

Abstract

The CD4-binding site antibody VH3810109 (N6LS) demonstrated broad and potent neutralization activity

Indexed as

Antibodies, NeutralizingBroadly Neutralizing AntibodiesAdultFemaleHIV-1HIV InfectionsHumansHyaluronoglucosaminidaseInjections, SubcutaneousMaleMiddle AgedYoung AdultAntibodies, NeutralizingBroadly Neutralizing AntibodiesHyaluronoglucosaminidaseADAbNAbinjection site reactionN6LSNRSpharmacokineticssafety

Identifiers

PMID40698814
PMCPMC12406676

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.