ArticleJournal of clinical laboratory analysis2025
Sex-Specific Associations of Serum Alkaline Phosphatase With Metabolic Syndrome and Its Components: Over 15 Years of Follow-Up Among Iranian Adults.
Article in Journal of clinical laboratory analysis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Hybrid intelligent systems for liver disease prediction: a demographic-aware machine learning framework.Frontiers in medicine · 2025Article
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6 authors.
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Abstract
backgroundTo investigate the association of serum alkaline phosphatase (ALP) with incident metabolic syndrome (MetS) and its components, as well as the influence of sex on this relationship among Iranian adults.
methodsThe multivariable Cox proportional hazards regression models were applied to assess the associations between ALP both as continuous and categorical variables with incident MetS and its components.
resultsAmong 831 subjects (467 women) with a mean age of 44.51 years, during a median follow-up of 15.6 years, 597 MetS cases (336 women) occurred. Interaction was found between ALP quartiles and sex (p-value = 0.006). Among women, increasing levels of ALP across the second to fourth quartiles were associated with hazard ratios (HRs) of 1.269, 1.491, and 2.092 for MetS, respectively (p for trend < 0.001). Among men, no association was found between ALP and incident MetS. Among women, the second and fourth quartiles of ALP were associated with incident high triglycerides (TG), with HRs of 1.793 and 1.815, respectively. Moreover, a 1-SD increase in ALP conferred a 17.9% higher risk of low high-density lipoprotein cholesterol (HDL-C). Among men, a 1-SD increase in ALP was associated with an HR of 1.222 for incident high waist circumference (WC) (All p-values < 0.05).
conclusionSex significantly influenced the impact of serum ALP on the incidence of MetS and its components. In women, ALP was a strong harbinger for incident MetS and its dyslipidemia components. However, among men, the increasing value of ALP was associated with incident central obesity but not MetS.
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