Evidence map›Paper›PMID 40698747›Full record

ArticleEuropean journal of neurology2025

The Phenomenology of Tics in Adults: Data From the Calgary and Paris Adult Tic Disorders Registry.

Christelle Nilles, Yulia Worbe, Andreas Hartmann, Davide Martino, Julian Fletcher, Naoual Serari, Catherine Deans, Isabella Davenport, Emmanuel Roze, Tamara Pringsheim

Abstract read
In one paragraph

Article in European journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Christelle NillesDepartment of Neurology, Hôpital Fondation Rothschild, Paris, France.ORCID 0000-0001-5834-3266
Yulia WorbeCentre de Référence National Maladie Rare 'Syndrome Gilles de la Tourette', Hôpital de la Pitié-Salpêtrière, Paris, France.
Andreas HartmannCentre de Référence National Maladie Rare 'Syndrome Gilles de la Tourette', Hôpital de la Pitié-Salpêtrière, Paris, France.
Davide MartinoDepartment of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada.ORCID 0000-0002-2217-0487
Julian FletcherDepartment of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada.
Naoual SerariDépartement de Neurologie, Hôpital de la Pitié-Salpêtrière, Paris, France.
Catherine DeansDepartment of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada.
Isabella DavenportDepartment of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada.
Emmanuel RozeFaculté de Santé, INSERM U 1127, CNRS UMR 7225, UM 75, ICM, Sorbonne Université, Paris, France.
Tamara PringsheimDepartment of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada.ORCID 0000-0002-8229-8431

Funding

Association Francaise du Syndrome Gilles de La TouretteUniversity of Calgary Owerko Centre for Neurodevelopment and Child Mental Health
6 · The paper itself

Abstract

introductionThis study investigated the phenomenology of tics in adults with primary tic disorders (Tourette syndrome, persistent motor or phonic tic disorders) and how these features are influenced by sex. It also examined the prevalence of comorbid psychiatric conditions and psychotropic medication use.

methodsA cross-sectional study was conducted on 227 adults with primary tic disorders from the Calgary and Paris Adult Tic Registry. Data collected included demographics, tic characteristics (using the Yale Global Tic Severity Scale), psychiatric comorbidities, and medication use. Statistical analyses were performed to compare data between sexes.

resultsThe sex ratio was 1.8 males to 1 female. The most common motor tics were simple (eye blinking, simple head movements), and the most common phonic tic was throat clearing. There were no significant sex differences in tic phenomenology or severity. Generalized anxiety disorder (49.5%) and attention deficit hyperactivity disorder (ADHD) (35.8%) were the most common comorbidities. A lower proportion of women were diagnosed with ADHD, while a higher proportion were diagnosed with obsessive compulsive disorder.

conclusionThe male predominance of tic disorders is less marked in adulthood compared to childhood. Tic phenomenology and severity do not significantly differ between sexes. These findings provide valuable insights into the clinical presentation of tic disorders in adults. Future research will explore severity of comorbid mental health conditions, how these influence tic severity, treatment outcomes and quality of life.

Indexed as

Tic DisordersTicsAdolescentAdultAgedAttention Deficit Disorder with HyperactivityComorbidityCross-Sectional StudiesFemaleHumansMaleMiddle AgedParisRegistriesYoung AdultadultsphenomenologysexticsTourette syndrome

Identifiers

PMID40698747
PMCPMC12284832

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.