ReviewPhysiological research2025
Mechanism study of acupuncture and acupuncture combined with medication in the treatment of ulcerative colitis.
Review in Physiological research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Electroacupuncture ameliorates ulcerative colitis by suppressing ferroptosis via the JAK2/STAT3 signaling pathway.Chinese medicine · 2026Article
- Electroacupuncture Attenuates Colitis in Mice Through Activation of Vagus Cholinergic Antiinflammatory Pathways.Journal of inflammation research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ulcerative colitis (UC) is a chronic inflammatory bowel disorder. Currently, the global incidence of UC has significantly increased. Traditional treatment methods are relatively limited, with generally poor efficacy and many side effects. In contrast, acupuncture holds great promise due to its significant efficacy, reduced relapse rate, and minimal side effects. In recent years, basic research on acupuncture treatment for UC has achieved substantial progress. However, the specific targets and pathways involved are still unclear. Therefore, this review aims to summarize and consolidate the mechanisms of acupuncture and acupuncture combined with drug therapy for UC. We primarily review the mechanisms of acupuncture treatment for UC from two aspects: intestinal inflammation and intestinal barrier. In terms of intestinal inflammation, acupuncture improves UC by regulating various inflammatory molecules such as TNF-alpha, IL-1beta, IL-10, NF-kappaB, and immune cells such as neutrophils, Th1, Th2, Treg, Th17. Concerning the intestinal barrier, we focus on the impact of acupuncture on the damage to intestinal epithelial cells (IECs). Moreover, acupuncture also possesses the capacity to reshape the gut microbiota, thereby repairing the biological barrier. Furthermore, the combination of acupuncture and medication for treating UC is a promising direction, which requires further exploration by researchers. This review thoroughly explains the molecular mechanisms of acupuncture in treating UC, establishing a foundation for further research on the effectiveness of acupuncture in UC treatment and offering a new perspective on the combination of acupuncture and medication. Key words Acupuncture " Electroacupuncture " Ulcerative colitis " Intestinal inflammation " Intestinal barrier.
Indexed as
Identifiers
40698655PMC12462699What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.