Evidence map›Paper›PMID 40698638›Full record

ArticleAmerican journal of hypertension2026

Arterial Stiffness and Central Hemodynamics in South Asian, African American, and White Adolescents and Young Adults-The Charisma Study.

Andrea Kelly, Ahtish Arputhan, Babette S Zemel, Samuel S Gidding, Raymond R Townsend, Sheela N Magge

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of hypertension, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Andrea KellyDivision of Endocrinology & Diabetes, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.ORCID 0000-0003-1724-9868
Ahtish ArputhanDivision of Endocrinology & Diabetes, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Babette S ZemelDepartment of Pediatrics, Perelman School of Medicine of University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-6164-7348
Samuel S GiddingDepartment of Genomic Health, Geisinger, Danville, Pennsylvania, USA.
Raymond R TownsendDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Sheela N MaggeDivision of Pediatric Endocrinology and Diabetes, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Funding

QAQC Johns Hopkins Institute for Clinical and Translational ResearchUL1TR003098 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2019 to 2023
$57.7M
Institutional Clinical and Translational Science AwardUL1TR000003 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2012 to 2015
$38.9M
Cardiometabolic Health in Adolescents of South Asian Ancestry - the CHAriSmA studyR01DK115648 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI MAGGE, SHEELA NATESH · 2018 to 2022
$3.9M
Cardiometabolic Risk Factors and Obesity in Adolescents with Down SyndromeR01HD071981 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI KELLY, ANDREA BRIDGET, MAGGE, SHEELA NATESH · 2012 to 2016
$2.8M
NCATS NIH HHS UL1TR000003NCATS NIH HHS UL1TR003098NCRR NIH HHSNICHD NIH HHS R01 HD071981NIDDK NIH HHS R01 DK115648NIH HHS DK115648Research Electronic Data Capture
6 · The paper itself

Abstract

backgroundCompared to individuals of European or African ancestry, individuals of South Asian (SA) ancestry have greater cardiovascular disease (CVD) risk. We aimed to compare arterial stiffness and central hemodynamics, surrogates of CVD, in adolescents and young adults (AYA) of SA, White, and African American (AA) ancestry with overweight or obesity.

methodsPulse wave velocity (PWV) and pulse wave analysis (PWA metrics: Pulse Pressure Amplification [PPA]; Augmentation Index adjusted to heart rate of 75 [Aix75]) were performed in a cross-sectional study of 40 (18M/22F) SA, 45 (16M/29F) AA, and 44 (21M/24F) White AYA (age 12-21 years) of comparable age, sex, and BMI. Between-group comparisons of PWV, PPA, and AIx-75 were tested using linear regression models adjusted for covariates (BMI, mean arterial pressure, sex, age), as appropriate.

resultsAs expected, BMI (kg/m2) did not differ (SA: 27.1, AA: 28.4, White: 27.4). Mean PWV (m/s) did not differ in SA (5.5), AA (5.1), and White (5.5). The typical relationship of BMI with PWV was absent in SA. PPA was lower in SA (1.45, P = 0.001) and AA (1.48, P = 0.014) vs. White (1.56). Aix75 was higher in SA (108, P = 0.004) but not in AA (105, P = 0.12) vs. White (101).

conclusionsAlthough their PWV did not differ, SA AYA had lower PPA and higher Aix75 compared to White counterparts. As lower PPA associates with higher likelihood of future CV events, these findings could reflect an early CVD predisposition in SA and underscore the potential value of pulse waveform analysis in studies of emerging adults, a life stage in which interventions may mitigate CVD risk.

Indexed as

AsianBlack or African AmericanCardiovascular DiseasesHemodynamicsVascular StiffnessWhiteAdolescentAge FactorsChildCross-Sectional StudiesFemaleHumansMalePulse Wave AnalysisYoung Adultadolescentsarterial stiffnessblood pressurecardiovascular diseasehypertensionobesitypulse wave analysispulse wave velocitySouth Asian

Identifiers

PMID40698638
PMCPMC12802940

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.