ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
Additive Manufactured Magnetoelectric Wireless Retainer as the Periodontal Remodeler for Post-Orthodontic Tissue Reconstruction and Relapse-Inhibition.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- A DMAHDM-herbal hybrid gargle for orthodontic-associated complications via oral microbiota regulation, inflammation inhibition, and enamel protection.Materials today. Bio · 2026Article
- Magnetoelectric nanoparticles drive TAF9BScience advances · 2026Article
- Additive Manufactured Magnetoelectric Wireless Retainer as the Periodontal Remodeler for Post-Orthodontic Tissue Reconstruction and Relapse-Inhibition.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Modern orthodontics since 1899 has failed to solve rapid and persistent dentition maintenance after tooth movement till now. Traditional post-orthodontic retention using single mechanical fixation cannot actuate periodontal tissue remodel, causing lifelong dependence, huge time costs and discomforts. Current attempts by combining hormone drug with mechanical fixation for improvement are limited by unsatisfactory outcomes and global side effects. Targeting at this 120-year dilemma, a flexible magnetoelectric orthodontic retainer (FMOR) is presented using customized additive manufacturing, serving as periodontal remodeler for high-performance post-orthodontic retention. Wireless magnetoelectric cues display considerable effects in periodontal microenvironment remodel, switching periodontal ligament cell (PDLC) paracrine manner to promote M2 macrophage formation, osteoclastic/osteoblastic balance and collagen metabolism. Using rat and rabbit orthodontic model, application of FMOR is confirmed to significantly strengthen the maintaining of tooth movement outcomes. Mechanistically, magnetoelectric treatment significantly upregulate PDLC genes related to immune response, extracellular matrix organization and osteogenic regulation. This study proposes a non-destructive physical therapeutic strategy for fast activation of periodontal reconstruction after orthodontic treatment and inhibition of tooth relapse for the first time, shedding light on development of next-generation orthodontic retention system for optimized solution of orthodontic relapse.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.