Evidence map›Paper›PMID 40698401›Full record

ArticleAddiction (Abingdon, England)2025

Unpacking the link between substance use disorders and 30-day unplanned readmission.

Allison D Rosen, Sae Takada, Catherine Juillard, Yulsi L Fernandez Montero, Amy M Richards, Serge Ngekeng, Steven J Shoptaw, Michelle A Bholat

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Addiction (Abingdon, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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  3. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Allison D RosenDepartment of Family Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0002-1630-0222
Sae TakadaDivision of General Internal Medicine, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Catherine JuillardProgram for the Advancement of Surgical Equity, Department of Surgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Yulsi L Fernandez MonteroDepartment of Family Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Amy M RichardsDepartment of Family Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Serge NgekengSustainable Trauma Research, Education, and Mentorship (STREaM) Program, Department of Public Health and Hygiene, University of Buea, Buea, Cameroon.
Steven J ShoptawDepartment of Family Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0002-3583-0026
Michelle A BholatDepartment of Family Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.

Funding

UCLA Department of Family Medicine
6 · The paper itself

Abstract

BACKGROUND AND

aimsGiven the more than twofold increase in the prevalence of substance use disorders in the United States in the past decade, more hospital inpatients can be expected to carry substance use disorder diagnoses, necessitating evaluation of potential links to 30-day unplanned readmissions, a marker of quality of care. This study aimed to measure the association between substance use disorder diagnoses, discharge disposition and 30-day unplanned hospital readmissions.

designThis retrospective cohort study extracted data from electronic health records of all inpatients. The index admission was defined as a patient's first admission in 2022.

settingTwo urban, academic medical centers in Los Angeles, California, USA.

participantsAmong 22 108 inpatients aged 18 and over and who did not expire during the hospital stay, 7.4% had at least one substance use disorder. The median age was 58, and 56.1% identified as female. Most patients identified as white (43.3%), followed by 22.5% Hispanic/Latinx, 10.8% Asian and 9.1% Black; 14.3% identified as another race. MEASUREMENTS: The exposure was diagnosis of any substance use disorder at index admission. The outcome was 30-day unplanned readmission.

findingsPatients with any substance use disorder [adjusted risk ratio (aRR) = 1.24, 95% confidence interval (CI) = 1.05-1.45) and patients specifically with opioid use disorder (aRR = 1.40, 95% CI = 1.09-1.80) were more likely to have a 30-day unplanned readmission compared with patients without substance use disorders. When assessing an interaction with discharge disposition, the association only held for patients discharged to home/self-care (aRR = 1.33, 95% CI = 1.05-1.69). Among patients who had zero, one, two and three or more unplanned readmissions, 7.1%, 8.8%, 14.0% and 15.5% had a substance use disorder at their index admission, respectively (P < 0.001).

conclusionsIn the United States, hospital patients with substance use disorder diagnoses appear to have a higher risk of 30-day unplanned readmission to hospital and account for a disproportionate share of patients who have multiple unplanned readmissions than hospital patients without substance use disorder diagnoses.

Indexed as

Patient ReadmissionSubstance-Related DisordersAdolescentAdultAgedFemaleHumansLos AngelesMaleMiddle AgedPatient DischargeRetrospective StudiesYoung Adult30‐day unplanned readmissionsalcohol use disorderhospital dischargeopioid use disorderquality of caresubstance use disorders

Identifiers

PMID40698401
PMCPMC12586751

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.