ArticlePhysics and imaging in radiation oncology2025
First in vitro and in vivo experiments with ultra high-dose rate oxygen ion radiotherapy.
Article in Physics and imaging in radiation oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Superior tumor cell killing by oxygen ion beam irradiation compared to carbon ions and photons in pancreatic Cancer cells - An in vitro investigation.Clinical and translational radiation oncology · 2026Article
- Research progresses on FLASH radiotherapy and its application for the treatment of digestive system tumors.Discover oncology · 2026Review
- New modalities for ultra-high dose rate irradiation and FLASH experiments.Physics and imaging in radiation oncology · 2025Article
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Authors and funding
16 authors.
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Abstract
Within this study, we demonstrated the feasibility of ultra-high dose rate (UHDR) oxygen ion irradiation at three different levels of biological complexity. The difference in oxygen consumption between UHDR and standard dose rates (SDR) was negligible in a protein-enriched saline solution. For the studied conditions of dose, dose rate and linear energy transfer (LET), UHDR irradiation showed comparable efficacy to SDR in pancreatic cancer cell killing in vitro, along with inducing a similar tumor growth delay in vivo. These findings emphasize the potential of high-LET UHDR irradiation and support further investigation of oxygen ions at UHDR.
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