Evidence map›Paper›PMID 40698308›Full record

ArticleCJC open2025

Smoking, Colchicine and Postoperative Outcomes in Thoracic Surgery: Post Hoc Analysis of the COP-AF Randomized Controlled Trial.

Sandra Ofori, Michael K Wang, Ekaterine Popova, William F McIntyre, Matthew Chan, Daniel I Sessler, Veronesi Giulia, Mark Warwas, Kumar Balasubramanian, Vikas Tandon and 18 more

Erratum issued Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CJC open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT03310125 (Colchicine For The Prevention Of Perioperative Atrial Fibrillation In Patients Undergoing Thoracic Surgery), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03310125 phase3completednot on this map

Colchicine For The Prevention Of Perioperative Atrial Fibrillation In Patients Undergoing Thoracic Surgery (COP-AF)

TypeinterventionalSponsorPopulation Health Research InstituteRan2018 to 2023Enrolled3,209ConditionsAtrial Fibrillation, Atrial Flutter, Myocardial Injury After Non-Cardiac SurgeryArmsColchicine, Placebo
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

28 authors.

Sandra OforiPopulation Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
Michael K WangPopulation Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
Ekaterine PopovaInstitut de Recerca Sant Pau, Barcelona, Spain.
William F McIntyrePopulation Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
Matthew ChanThe Chinese University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China.
Daniel I SesslerOutcomes Research Consortium, Houston, Texas, USA.
Veronesi GiuliaDepartment of Thoracic Surgery, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Mark WarwasDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
Kumar BalasubramanianPopulation Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
Vikas TandonDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
Christain FinleyDepartment of Surgery, McMaster University, Hamilton, Ontario, Canada.
Gonzalez Tallada AnnaVall d'Hebron, Barcelona, Spain.
Juan CataUniversity of Texas, Houston, Texas, USA.
Sadeesh SrinathanUniversity of Manitoba, Winnipeg, Manitoba, Canada.
Cara ReimerKingston General Hospital, Kingston, Ontario, Canada.
Sean McLeanVancouver Acute Department of Anesthesia and Perioperative Medicine, Vancouver General Hospital, British Columbia, Canada.
Juan Carlos TrujilloThoracic Surgery Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Edith FleischmannMedical University of Vienna, Vienna, Austria.
Luca VoltoliniUniversity of Florence, Florence, Italy.
Patricia CruzDepartment of Anesthesiology, Reanimation and Pain treatment. University General Hospital Gregorio Marañón, Madrid, Spain.
Donna E MaziakUniversity of Ottawa, Surgical Oncology, Division of Thoracic Surgery, Ottawa, Ontario, Canada.
Laura Gutiérrez-SorianoAnesthesiology Department, Anesthesiology Research Group, Fundación Cardioinfantil-Instituto de Cardiología, Bogotá, Colombia.
Mohammed AmirShifa International Hospital, Shifa Tameer-e-Millat University, Islamabad, Pakistan.
Matthias BossardCardiology Division, Heart Center, Luzerner Kantonsspital, Lucerne, Switzerland.
Chew Yin WangDepartment of Anaesthesiology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.
P J DevereauxPopulation Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
David ConenPopulation Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
COP-AF investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: To determine, among patients who underwent major noncardiac thoracic surgery, the association between smoking and perioperative atrial fibrillation (AF) and myocardial injury after noncardiac surgery (MINS), and whether the effect of colchicine use on these outcomes varied by smoking status. Methods: This study is a subgroup analysis of the Colchicine for the Prevention of Perioperative Atrial Fibrillation (COP-AF) randomized clinical trial. A total of 3209 participants who underwent major noncardiac thoracic surgery were randomized to receive colchicine, 0.5 mg twice daily, or identical placebo, for 10 days starting 2-4 hours before surgery. The co-primary outcomes were clinically significant perioperative AF and MINS during the 14-day follow-up. Results: A total of 687 (21.4%) were current smokers, 1577 (49.1%) were former smokers, and 945 (29.5%) were never smokers. AF occurred in 7.7%, 7.6%, and 5.3%, and MINS occurred in 21.0%, 19.7%, and 17.6% of current, former, and never smokers, respectively. Compared to never smokers, the adjusted hazard ratio for AF was 1.72 (95% confidence interval [CI] 1.07-2.77, Conclusions: Current smoking was associated with a small but increased risk of perioperative AF but not MINS after thoracic surgery. The effect of colchicine use on either outcome was not modified by smoking status. Clinical Trial Registration: NCT03310125.

Identifiers

PMID40698308
PMCPMC12277807

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.