Evidence map›Paper›PMID 40698152›Full record

ArticleIJID regions2025

Molecular characterization and antimicrobial resistance of

Mitsuyo Kawaguchiya, Meiji Soe Aung, Noriko Urushibara, Nobuhide Ohashi, Nobuyuki Kobayashi, Kenji Kudo, Masahiko Ito, Nobumichi Kobayashi

Abstract read
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In one paragraph

Article in IJID regions, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mitsuyo KawaguchiyaDivision of Hygiene, Department of Social Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.
Meiji Soe AungDivision of Hygiene, Department of Social Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.
Noriko UrushibaraDivision of Hygiene, Department of Social Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.
Nobuhide OhashiDivision of Hygiene, Department of Social Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.
Nobuyuki KobayashiMedical Laboratory and Blood Center, Asahikawa Medical University Hospital, Asahikawa, Japan.
Kenji KudoSapporo Clinical Laboratory, Inc., Sapporo, Japan.
Masahiko ItoSapporo Clinical Laboratory, Inc., Sapporo, Japan.
Nobumichi KobayashiDivision of Hygiene, Department of Social Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: This study aimed to elucidate the molecular characteristics and antimicrobial resistance of Methods: A total of 45 isolates obtained from adults (aged 41-98 years) with IPD between 2017 and 2023 were analyzed for serotype, sequence type (ST), and antimicrobial susceptibility. Results: Of the 45 isolates, serotype 3-ST180 (24.4%) was the most prevalent, followed by 23A-ST338/ST5242 (13.3%); 23F-ST242/ST1437/ST3543 (8.9%); and 6D-ST282, 15A-ST63, 35B-ST558, and 34-ST1439/ST7388 (6.7% each), which collectively accounted for 73.4% of all isolates. The proportion of the pneumococcal conjugate vaccine (PCV) 13, PCV20, and 23-valent polysaccharide vaccine (PPSV23) serotypes were 44.5%, 46.7%, and 44.5%, respectively. The rate of non-susceptibility to penicillin was 24.4%, and the majority (n = 10 of 11, 90.9%) were also non-susceptible to erythromycin and tetracycline. The multidrug resistance rate for the non-PCV20/PPSV23 serotype was 83.3%, which was higher than the 71.4% for the vaccine serotypes. Among the non-PCV20/PPSV23 serotypes, 23A, 6D, 15A, 35B, and 6E (genetic variant of 6B) showed multidrug resistance with non-susceptibility to penicillin. Conclusions: The present study revealed that the non-vaccine serotypes in IPD among adults were associated with a high prevalence of non-susceptibility to antimicrobial agents, suggesting the need for continuous surveillance.

Indexed as

Invasive pneumococcal diseaseJapanMultidrug resistanceSequence typeSerotype

Identifiers

PMID40698152
PMCPMC12280404

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.