Evidence map›Paper›PMID 40698130›Full record

ArticleActa pharmaceutica Sinica. B2025

Discovery of

Yunjun Ge, Huiwen Guan, Ting Li, Jie Wang, Liang Ying, Shuhui Guo, Jinjian Lu, Richard D Ye, Guosheng Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yunjun GeDepartment of Basic Medical Science, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu 214122, China; MoE Medical Basic Research Innovation Center for Gut Microbiota and Chronic Diseases, School of Medicine, Wuxi 214122, China.
Huiwen GuanDepartment of Basic Medical Science, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu 214122, China; MoE Medical Basic Research Innovation Center for Gut Microbiota and Chronic Diseases, School of Medicine, Wuxi 214122, China.
Ting LiState Key Laboratory for Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR 999078, China.
Jie WangDepartment of Basic Medical Science, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu 214122, China; MoE Medical Basic Research Innovation Center for Gut Microbiota and Chronic Diseases, School of Medicine, Wuxi 214122, China.
Liang YingDepartment of Basic Medical Science, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu 214122, China; MoE Medical Basic Research Innovation Center for Gut Microbiota and Chronic Diseases, School of Medicine, Wuxi 214122, China.
Shuhui GuoShenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518172, China.
Jinjian LuState Key Laboratory for Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR 999078, China.
Richard D YeKobilka Institute of Innovative Drug Discovery, School of Medicine, the Chinese University of Hong Kong, Shenzhen 518172, China.
Guosheng WuDepartment of Basic Medical Science, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu 214122, China; MoE Medical Basic Research Innovation Center for Gut Microbiota and Chronic Diseases, School of Medicine, Wuxi 214122, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

G protein-coupled receptors (GPCRs) are significant drug targets, but their potential in cancer therapy remains underexplored. Conventional GPCR agonists or antagonists have shown limited effectiveness in cancer treatment, necessitating new GPCR-targeting strategies for more effective therapies. This study discovers that

Indexed as

Biased agonistConformational changeFormyl peptide receptor 1G proteinG protein-coupled receptorSignaling pathwayTherapeutic strategyYersinia LcrV

Identifiers

PMID40698130
PMCPMC12278436

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.