Evidence map›Paper›PMID 40698094›Full record

ReviewRomanian journal of ophthalmology

The role of matrix metalloproteinases in the modulation of aqueous humor in glaucoma patients.

Cerbulescu Teodor, Barac Ileana Ramona, Boruga Ovidiu, Sălăvăţ Mădălina Casiana, Leuştean Laurenţiu, Duncă Ştefan Daciana, Calancea Andrei, Barac Andreea Diana

Abstract readReview
In one paragraph

Review in Romanian journal of ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Cerbulescu Teodor"Victor Babeş" University of Medicine and Pharmacy, Timişoara, Romania.
Barac Ileana Ramona"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
Boruga Ovidiu"Victor Babeş" University of Medicine and Pharmacy, Timişoara, Romania.
Sălăvăţ Mădălina Casiana"Victor Babeş" University of Medicine and Pharmacy, Timişoara, Romania.
Leuştean Laurenţiu"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
Duncă Ştefan Daciana"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
Calancea Andrei"Iuliu Hațieganu" University of Medicine and Pharmacy, Cluj, Romania.
Barac Andreea Diana"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Matrix metalloproteinases are crucial proteolytic enzymes involved in the degradation and remodeling of the extracellular matrix within the ocular structures. Their expression and activity significantly influence aqueous humor dynamics and intraocular pressure in patients with glaucoma. Elevated intraocular pressure, a significant risk factor for glaucoma, is often associated with disturbed aqueous humor outflow. This review summarizes current findings on the role of matrix metalloproteinases in modulating aqueous humor and their potential as therapeutic targets in the treatment of glaucoma.

Indexed as

Aqueous HumorGlaucomaIntraocular PressureMatrix MetalloproteinasesHumansMatrix Metalloproteinasesaqueous humor dynamicsECM = extracellular matrixextracellular matrix remodelingglaucomaintraocular pressureIOP = Intraocular PressureJEP = Journal of Experimental Pharmacologymatrix metalloproteinasesMMP = Matrix MetalloproteinaseOPTH = Clinical OphthalmologyPMCID = PubMed Central IdentifierPMID = PubMed IdentifierTIMP = Tissue Inhibitor of Metalloproteinase

Identifiers

PMID40698094
PMCPMC12277996

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.