Evidence map›Paper›PMID 40698033›Full record

ArticleOpen forum infectious diseases2025

Genomic and Phenotypic Characterization of Mupirocin-resistant

Ariana M Virgillio, Emily A Felton, Jessica K Jackson, Sarah J Kennedy, Deanna N Becker, Amorce Lima, Kimberly Atrubin, Eleonora Cella, Taj Azarian, Suzane Silbert and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open forum infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Ariana M VirgillioDivision of Infectious Disease and International Medicine, University of South Florida, Tampa, Florida, USA.ORCID https://orcid.org/0009-0003-2431-6915
Emily A FeltonCenter for Antimicrobial Resistance, University of South Florida, Tampa, Florida, USA.
Jessica K JacksonDepartment of Molecular Biosciences, University of South Florida, Tampa, Florida, USA.
Sarah J KennedyDepartment of Molecular Biosciences, University of South Florida, Tampa, Florida, USA.
Deanna N BeckerTampa General Hospital, Tampa, Florida, USA.ORCID https://orcid.org/0009-0003-0927-5836
Amorce LimaTampa General Hospital, Tampa, Florida, USA.
Kimberly AtrubinTampa General Hospital, Tampa, Florida, USA.
Eleonora CellaBurnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida, USA.
Taj AzarianBurnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida, USA.ORCID https://orcid.org/0000-0002-8611-5241
Suzane SilbertTampa General Hospital, Tampa, Florida, USA.
Lindsey N ShawCenter for Antimicrobial Resistance, University of South Florida, Tampa, Florida, USA.ORCID https://orcid.org/0000-0002-0629-8990
Kami KimDivision of Infectious Disease and International Medicine, University of South Florida, Tampa, Florida, USA.ORCID https://orcid.org/0000-0003-3384-152X

Funding

The Role and Regulation of Extracellular Proteases in Staphylococcus aureusR01AI124458 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI SHAW, LINDSEY NEIL · 2017 to 2020
$1.7M
Dissecting the Influence of a C-Terminal Processing Protease on S. aureus PathogenesisR01AI157506 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI SHAW, LINDSEY NEIL · 2021 to 2024
$1.5M
NIAID NIH HHS R01 AI124458NIAID NIH HHS R01 AI157506
6 · The paper itself

Abstract

Background: Colonization with Methods: We characterized oxacillin and mupirocin susceptibility amongst 384 Results: Mupirocin resistance (MupR) was nearly exclusively present in MRSA strains (103/106, 97.1% of MupR; 103/299, 34.4% of MRSA). Although our hospital protocol for decolonization shifted to povidone iodine in the post-COVID period, the overall prevalence of MupR did not change in pre-COVID and post-COVID samples (28.9% vs 26%). Genotype correlated with antibiotic susceptibility with low-level MupR, linked to mutations in Conclusions: Mupirocin resistance was prevalent in our hospital MRSA strains. We also found evidence for emergence and persistence of ST3390 MRSA-MupR strains in Florida.

Indexed as

antimicrobial resistancedecolonizationMRSAmupirocinstaphylococcus aureus

Identifiers

PMID40698033
PMCPMC12282342

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.