ReviewCurrent research in toxicology2025
Neural organoids as advanced tools for neurotoxicity modeling.
Review in Current research in toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Article
- Integrated New Approach Methodologies Reveal the Potential Role of 2,7-Dibromocarbazole in Parkinson's Disease via Monoamine Oxidase B Inhibition and Dopaminergic Dysfunction.Environmental science & technology · 2026Article
- Editorial: Pluripotent stem cells in discovery and mechanistic toxicology.Current research in toxicology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurotoxicity studies often depend on traditional cell-based monoculture assays and animal models, which have a number of limitations. In particular, the existing models either lack the appropriate physiological context, do not include a functional blood-brain barrier, or include cells from non-human species. The recent emergence of organoids derived from human pluripotent stem cells has provided new opportunities to understand disease etiology, discover drugs, evaluate efficacy, and evaluate toxicity in physiologically relevant contexts. Organoids comprised of organ specific precursor cells can potentially overcome the limitations of the traditional 2D cell culture and animal models in neurotoxicology studies. Here, we provide a review of recent developments of human neural organoids, and summarize their applications in neurotoxicity testing. We also discuss their several limitations, and provide a future perspective on their widespread use in neurotoxicity studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.