Evidence map›Paper›PMID 40698007›Full record

ArticleJAC-antimicrobial resistance2025

Combatting mobile colistin-resistant (MCR), metallo-β-lactamase (MBL)-producing

Jack F Klem, Jan Naseer Kaur, Yang Liu, Katie Rose Boissonneault, Shivali Kapoor, Patricia N Holden, Albert Chen, Yanan Zhao, Liang Chen, Nicholas M Smith and 1 more

Abstract read
In one paragraph

Article in JAC-antimicrobial resistance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jack F KlemCenter for Infectious Diseases and Next-Generation Therapeutics, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY, USA.ORCID https://orcid.org/0000-0002-8741-0250
Jan Naseer KaurCenter for Infectious Diseases and Next-Generation Therapeutics, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY, USA.
Yang LiuCenter for Infectious Diseases and Next-Generation Therapeutics, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY, USA.
Katie Rose BoissonneaultCenter for Infectious Diseases and Next-Generation Therapeutics, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY, USA.
Shivali KapoorCenter for Infectious Diseases and Next-Generation Therapeutics, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY, USA.
Patricia N HoldenCenter for Infectious Diseases and Next-Generation Therapeutics, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY, USA.
Albert ChenCenter for Infectious Diseases and Next-Generation Therapeutics, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY, USA.
Yanan ZhaoCenter for Infectious Diseases and Next-Generation Therapeutics, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY, USA.
Liang ChenCenter for Infectious Diseases and Next-Generation Therapeutics, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY, USA.ORCID https://orcid.org/0000-0001-5845-2235
Nicholas M SmithCenter for Infectious Diseases and Next-Generation Therapeutics, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY, USA.ORCID https://orcid.org/0000-0002-0212-2787
Brian T TsujiCenter for Infectious Diseases and Next-Generation Therapeutics, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY, USA.

Funding

Novel Biamyxins targeting multidrug resistant Gram-negative bacterial infectionsR01AI182297 · NIAID · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI Yanan Zhao · 2024 to 2026
$2.4M
Pharmacokinetics and Pharmacodynamics of Mechanistically Aware Phage CocktailsR01AI177997 · NIAID · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI Nicholas Michael Smith · 2024 to 2026
$2.2M
NIAID NIH HHS R01 AI177997NIAID NIH HHS R01 AI182297
6 · The paper itself

Abstract

Objectives: Therapeutic modalities for pan-drug-resistant Gram-negatives co-expressing mobile colistin resistance and metallo-β-lactamases have not been defined. Here, we devised novel strategies involving aztreonam and ceftazidime/avibactam together with polymyxin B to combat persisters of a pan-drug-resistant Methods: A hollow fibre infection model was utilized to profile the clinical combination of aztreonam + ceftazidime/avibactam + polymyxin B against a pan-drug-resistant Results: The clinical combination of aztreonam + ceftazidime/avibactam demonstrated initial activity with a total count reduction of 2.69 log Conclusions: Despite intrinsic

Identifiers

PMID40698007
PMCPMC12280553

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.